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Cat. No.: HY-131691

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NMDAR blocker 1

NMDAR blocker 1 is an NMDA receptor channel blocker with an IC₅₀ of 5.0 μM. NMDAR blocker 1 exhibits fast on-off blockade kinetics and strong voltage dependence, and does not compete with glutamate or glycine. NMDAR blocker 1 prevents glutamate/NMDA-induced intracellular Ca²⁺ overload, modulates the glutamate-nitric oxide-cGMP pathway. NMDAR blocker 1 prevents in vitro excitotoxic neurodegeneration of cultured cerebellar and hippocampal neurons. NMDAR blocker 1 attenuates excitotoxic insult in an mouse model of hyperammonemia-induced excitotoxicity. NMDAR blocker 1 can be used for the research of neurodegenerative diseases.

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CAS No.: 76991-05-4
화학식: C₁₇H₂₀N₂O
분자량:268.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NMDAR blocker 1 Chemical Structure

CAS No.: 76991-05-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

NMDA Receptor

All iGluR Isoforms :

All Calcium Channel Isoforms :

In Vitro

NMDAR blocker 1 (Compound N20C) (5-500 μM) potently and selectively inhibits rat NR1/NR2A NMDA receptor channel activity in Xenopus laevis oocytes with an IC₅₀ of 5.0 ± 0.2 μM^[1].
NMDAR blocker 1 (0.1-100 μM; 4 h) protects primary rat cerebellar and hippocampal neuron cultures from excitotoxic death, with maximal 85 ± 6% survival of cerebellar neurons at 30 μM^[1].
NMDAR blocker 1 (0.01-30 μM; 5 min) dose-dependently inhibits NMDA-induced cGMP formation in primary rat cerebellar neurons^[1].
NMDAR blocker 1 (0.01-100 μM; 10 min) potently blocks NMDA-induced intracellular Ca²⁺ overload in primary rat cerebellar neurons, with complete inhibition at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NMDAR blocker 1 (Compound N20C) (5-50 μg/g; i.p.; single dose) provides dose-dependent in vivo neuroprotection against acute ammonia-induced excitotoxicity in male Swiss mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ammonia-induced Swiss mice (male, 25-35 g)^[1]
Dosage:

5 μg/g; 10 μg/g; 30 μg/g; 50 μg/g
Administration:

i.p.; single dose
Result:

Increased survival rate.
Caused no conspicuous behavioral or motor deficits in treated animals.

Related Protocols :

Chemical Information

CAS No. 76991-05-4
분자량 268.36
화학식 C₁₇H₂₀N₂O
SMILES

O=C(N)CNCCC(C=1C=CC=CC1)C=2C=CC=CC2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Planells-Cases R, et al. A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity. J Pharmacol Exp Ther. 2002;302(1):163-173. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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NMDAR blocker 1

All iGluR Isoforms

All Calcium Channel Isoforms