1. Anti-infection
  2. HBV
  3. NVR 3-778

NVR 3-778 

Cat. No.: HY-124600
Handling Instructions

NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator) belonging to the SBA (sulfamoylbenzamide) class, with anti-HBV activity.

For research use only. We do not sell to patients.

NVR 3-778 Chemical Structure

NVR 3-778 Chemical Structure

CAS No. : 1445790-55-5

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NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator) belonging to the SBA (sulfamoylbenzamide) class, with anti-HBV activity[1].

IC50 & Target


In Vitro

NVR 3-778 targets HBV core protein and inhibits viral replication[1].
NVR 3-778 inhibits the generation of infectious HBV DNA-containing virus particles with a mean antiviral with an EC50 of 0.40 µM in HepG2.2.15 cells[1].
NVR 3-778 exhibits pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication[1].
NVR 3-778 inhibits pregenomic RNA encapsidation, viral replication, and the production of HBV DNA- and HBV RNA-containing particles[1].
NVR 3-778 also inhibits de novo infection and viral replication in primary human hepatocytes with EC50s of 0.81 µM against HBV DNA and between 3.7µM and 4.8 µM against the production of HBV antigens and intracellular HBV RNA[1].
The EC50 values of NVR 3-778 are increased by 4.5-, 9.3-, and 15.8-fold in the presence of 10%, 20%, and 40% human serum, respectively[1].

In Vivo

NVR 3-778 (1.5 mg/kg; i.g.) displays the mean Cmax and AUC0–inf values of 0.56 µg/ml and 3.50 µg·h/ml, respectively, in dogs following oral administration. And the mean oral bioavailability is determined to be 84.6%[1].

Animal Model: Dogs[1]
Dosage: 1.5 mg/kg (Pharmacokinetic Analysis)
Administration: Oral gavage
Result: The mean Cmax and AUC0–inf values are 0.56 µg/ml and 3.50 µg·h/ml and the oral bioavailability is 84.6%.
Molecular Weight









Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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NVR 3-778HBVHepatitis B virusHepatitisBviruscapsidassemblymodulatorCAMchronichepatitisInhibitorinhibitorinhibit

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