1. Immunology/Inflammation
    Anti-infection
  2. PD-1/PD-L1
    HBV
  3. PD-1/PD-L1-IN 7

PD-1/PD-L1-IN 7 

Cat. No.: HY-138407 Purity: 98.48%
Handling Instructions

PD-1/PD-L1-IN 7 is a human PD-1/PD-L1 protein/protein interaction inhibitor with an IC50 of 0.213 nM. PD-1/PD-L1-IN 7 has anticancer and antiviral functions.

For research use only. We do not sell to patients.

PD-1/PD-L1-IN 7 Chemical Structure

PD-1/PD-L1-IN 7 Chemical Structure

CAS No. : 2374856-75-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 730 In-stock
Estimated Time of Arrival: December 31
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

PD-1/PD-L1-IN 7 is a human PD-1/PD-L1 protein/protein interaction inhibitor with an IC50 of 0.213 nM. PD-1/PD-L1-IN 7 has anticancer and antiviral functions[1].

IC50 & Target

IC50: 0.213 nM (Human PD-1/PD-L1 protein/protein interaction)[1]

In Vitro

PD-1/PD-L1-IN 7 (compound 139) enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. PD-1/PD-L1-IN 7 also enhances the frequency of GrB+ cells among HBV-specific CD8+ and CD4+ T cells. The ability of PD-1/PD-L1-IN 7 to enhance the antiviral functions of HBV-specific CD8+ and CD4+ T cells in vitro is comparable to those of Durvalumab[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PD-1/PD-L1-IN 7 (Compound 139; 10-50 mg/kg; intraperitoneal injection, daily, for 6 days) treatment shows >90% PD-L1 target occupancy (TO) on the tumor cells. PD-1/PD-L1-IN 7 significantly inhibits tumor growth in a human PD-L1 expressing MC38 mouse colorectal tumor model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice injected with MC38 tumor cells[1]
Dosage: 10 mg/kg, 25 mg/kg, and 50 mg/kg
Administration: Intraperitoneal injection, daily, for 6 days
Result: Showed greater than 90% TO on the tumors and inhibited tumor growth in vivo.
Molecular Weight

691.61

Formula

C₃₄H₃₆Cl₂N₈O₄

CAS No.

2374856-75-2

SMILES

ClC1=C(C(C=CC=C2C(C=N3)=NC(OC)=C3CNC[[email protected]](CC4)NC4=O)=C2Cl)C=CC=C1C(C=N5)=NC(OC)=C5CNC[[email protected]](CC6)NC6=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (72.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4459 mL 7.2295 mL 14.4590 mL
5 mM 0.2892 mL 1.4459 mL 2.8918 mL
10 mM 0.1446 mL 0.7230 mL 1.4459 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PD-1/PD-L1-IN 7PD-1/PD-L1HBVPD-1/Programmed death-ligand 1Hepatitis B virusPD-1PD-L1anticancerantiviralIFN-γPPIInhibitorinhibitorinhibit

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PD-1/PD-L1-IN 7
Cat. No.:
HY-138407
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