2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-15 Receptor
  6. IL-15R alpha

IL-15R alpha

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IL-15R alpha is a high affinity receptor for IL-15 (Kd: 100 pM)[1]. IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells[2]. IL-15R alpha plays an important role in memory CD8 T cell homeostasis and lymphocyte development[3].IL-15R alpha is expressed on various cell types, including lymphocytes, myeloid cells, nonlymphoid and nonhematopoietic cells[4]. Human IL-15R alpha consists of extracellular domain (I31-T205), helical domain (T206-L228), and cytoplasmic domain (K229-L267). Human IL-15R alpha shares <55% aa sequence identity with mouse. IL-15Rα is required for transporting of IL-15 from the endoplasmic reticulum to the cell surface[4]. When binding with IL-15, the complex increases the in vivo half-life of IL-15 and enhances binding affinity of IL-15 with IL-15Rβ/γ in NK cells and CD8+ T cells. Thus, the signal transmission improves proliferation and antitumor activities of NK cells and CD8+ T cells[2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70655
    IL-15R alpha & IL-15 Fusion Protein, Human (HEK293, Fc)

    IL15RA& IL15; Interleukin-15; IL-15; IL15; IL-15 receptor subunit alpha; IL-15RA; IL-15R-alpha; interleukin-15 receptor subunit alpha

    		Human HEK293
    IL-15R alpha is a high affinity receptor for IL-15 (Kd: 100 pM). IL-15 is essential for the development and function natural killer (NK) cell, NKT cell and memory (m) CD8+ T cell. IL-15R alpha maintains memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha/IL-15 complex can activate the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha & IL-15 Fusion Protein, Human (HEK293, Fc) is a recombinant human IL-15R alpha (I31-D96) & IL-15 (N49-S162) fusion protein with a C-Terminal hFc tag, which is produced in HEK293 cells.
  • HY-P77699
    IL-15R alpha & IL-15 Protein, Human (HEK293, His)

    IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha1; Interleukin-15; IL-15; IL15

    		Human HEK293
    IL-15R alpha is a high affinity receptor for IL-15 (Kd: 100 pM). IL-15 is essential for the development and function natural killer (NK) cell, NKT cell and memory (m) CD8+ T cell. IL-15R alpha maintains memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha/IL-15 complex can activate the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha & IL-15 Protein, Human (HEK293, His) is a recombinant human IL-15R alpha (I31-S108) & IL-15 (N49-S162) fusion protein with a C-Terminal His tag, which is produced in HEK293 cells.
  • HY-P78154
    IL-15R alpha Protein, Human (Biotinylated, HEK293, His-Avi)

    IL-15 R alpha; CD215; IL-15RA; MGC104179

    		Human HEK293
    IL-15R alpha is a high affinity receptor for IL-15 (Kd: 100 pM). IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha plays an important role in memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human extracellular region of IL-15R alpha (I31-T205) with a C-Terminal His-Avi tag, which is produced in HEK293 cells.
  • HY-P71978
    IL-15R alpha Protein, Mouse (HEK293, hFc)

    Il15ra; Interleukin-15 receptor subunit alpha; IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; CD antigen CD215; Soluble interleukin-15 receptor subunit alpha; sIL-15 receptor subunit alpha; sIL-15R-alpha; sIL-15RA;

    		Mouse HEK293
    IL-15R alpha is a high affinity receptor for IL-15 (Kd: 100 pM). IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha plays an important role in memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha Protein, Mouse (HEK293, hFc) is a recombinant mouse extracellular region of IL-15R alpha (G33-K205) with a C-Terminal hFc tag, which is produced in HEK293 cells.
  • HY-P77700
    IL-15R alpha & IL-15 Protein, Human (Biotinylated, HEK293, His)

    IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha1; Interleukin-15; IL-15; IL15

    		Human HEK293
    IL-15R alpha is a high affinity receptor for IL-15 (Kd: 100 pM). IL-15 is essential for the development and function natural killer (NK) cell, NKT cell and memory (m) CD8+ T cell. IL-15R alpha maintains memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha/IL-15 complex can activate the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha & IL-15 Protein, Human (Biotinylated, HEK293, His) is a recombinant biotinylated human IL-15R alpha (I31-S108) & IL-15 (N49-S162) fusion protein with a C-Terminal His tag, which is produced in HEK293 cells.
  • HY-P78468
    IL-15R alpha Protein, Human (HEK293, His-Avi)

    IL-15 R alpha; CD215; IL-15RA; MGC104179

    		Human HEK293
    IL-15R alpha is a high affinity receptor for IL-15 (Kd: 100 pM). IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha plays an important role in memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha Protein, Human (HEK293, His-Avi) is a recombinant human extracellular region of IL-15R alpha (I31-T205) with a C-Terminal His-Avi tag, which is produced in HEK293 cells.
  • HY-P701298
    FITC-Labeled IL-15R alpha Protein, Human (HEK293, Fc)

    IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha

    		Human HEK293
    IL-15R alpha Protein, a proven high-affinity receptor for interleukin-15, signals in both cis and trans. In neutrophils, it activates SYK kinase, crucial for IL-15-induced phagocytosis in a SYK-dependent manner. Different isoforms may introduce variations in signal transduction. Notably, IL-15R alpha Protein, while having high affinity, does not directly bind to IL15. FITC-Labeled IL-15R alpha Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled IL-15R alpha protein, expressed by HEK293 , with Fc labeled tag. The total length of FITC-Labeled IL-15R alpha Protein, Human (HEK293, Fc) is 175 a.a., with molecular weight of 60-80 kDa.
  • HY-P701299
    PE-Labeled IL-15R alpha Protein, Human (HEK293, Fc)

    IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha

    		Human HEK293
    IL-15R alpha Protein, a proven high-affinity receptor for interleukin-15, signals in both cis and trans. In neutrophils, it activates SYK kinase, crucial for IL-15-induced phagocytosis in a SYK-dependent manner. Different isoforms may introduce variations in signal transduction. Notably, IL-15R alpha Protein, while having high affinity, does not directly bind to IL15. PE-Labeled IL-15R alpha Protein, Human (HEK293, Fc) is the recombinant human-derived PE-Labeled IL-15R alpha protein, expressed by HEK293 , with Fc labeled tag. The total length of PE-Labeled IL-15R alpha Protein, Human (HEK293, Fc) is 175 a.a., with molecular weight of 46.6 kDa.
  • HY-P72592
    IL-15R alpha Protein, Human (142a.a, HEK293, Fc)

    Interleukin-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; CD215; sIL-15R-alpha; sIL-15RA

    		Human HEK293
    IL-15R alpha is a high affinity receptor for IL-15 (Kd: 100 pM). IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha plays an important role in memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha Protein, Human (142a.a, HEK293, Fc) is a recombinant human extracellular region of IL-15R alpha (I31-T172) with a C-Terminal Fc tag, which is produced in HEK293 cells.
Cat. No. Product Name Effect Purity