IL-15RA Antibody (YA7010)
(Synonyms: AA690181 antibody; CD215 antibody; I15RA_HUMAN antibody; IL 15R alpha antibody; IL-15 receptor subunit alpha antibody; IL-15R-alpha antibody; IL-15RA antibody; Il15ra antibody; Interleukin 15 receptor alpha antibody; Interleukin 15 receptor subunit alpha antibody)IL-15RA Antibody (YA7010) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL-15RA.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:50-1:200 |
Product Details
IL-15RA Antibody (YA7010) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL-15RA.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 28.2kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 28.2kDa
Purified recombinant fragment of human CD215 (AA: extra 31-205) expressed in E. Coli.
Endogenous
Protein G affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IL-15RA is a High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction |Does not bind IL15|Does not bind IL15|Does not bind IL15|Does not bind IL15[1][2][3].
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Subcellular Localization
Membrane,Nucleus membrane,Cell surface,Endoplasmic reticulum membrane,Golgi apparatus membrane,Cytoplasmic vesicle membrane,Membrane,Endoplasmic reticulum membrane,Golgi apparatus membrane,Cytoplasmic vesicle membrane,Membrane,Endoplasmic reticulum membrane,Golgi apparatus membrane,Cytoplasmic vesicle membrane,Membrane,Endoplasmic reticulum membrane,Golgi apparatus membrane,Cytoplasmic vesicle membrane,Membrane,Secreted, extracellular space
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Expression
Tissue_Specificity: Expressed in neutrophils (at protein level) (PubMed:15123770). Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus (PubMed:12114302). Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures (PubMed:12114302). Isoforms 1, 3, 4, 5, 6, 7, 8 and 9: Widely expressed (PubMed:10480910, PubMed:8530383) -
Isoforms & Post-Translational Modification
Q13261 has 9 isomers: Q13261-1: 28233 Da (predicted); Q13261-3: 24870 Da (predicted); Q13261-4: 26299 Da (predicted); Q13261-5: 22936 Da (predicted); Q13261-6: 20904 Da (predicted); Q13261-7: 18969 Da (predicted); Q13261-8: 17641 Da (predicted); Q13261-9: 15707 Da (predicted); Q13261-10: 24388 Da (predicted).
N-glycosylated and O-glycosylated丨A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (PubMed:15265897) -
Subunit
The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG
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SwissProt ID
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Synonyms
AA690181 antibody; CD215 antibody; I15RA_HUMAN antibody; IL 15R alpha antibody; IL-15 receptor subunit alpha antibody; IL-15R-alpha antibody; IL-15RA antibody; Il15ra antibody; Interleukin 15 receptor alpha antibody; Interleukin 15 receptor subunit alpha antibody
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