IL-15RA Antibody (YA7010)

Cat. No.: HY-P87327: Data Sheet User Guide for Antibodies
FAQs
Technical Support

IL-15RA Antibody (YA7010) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL-15RA.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

IL-15RA Antibody (YA7010) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL-15RA.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 28.2kDa;

Observed band size: 28.2kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q13261

Immunogen

Purified recombinant fragment of human CD215 (AA: extra 31-205) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200

Sensitivity	Endogenous	Purity	Protein G affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in in PBS with 0.05% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910)|Does not bind IL15|Does not bind IL15|Does not bind IL15|Does not bind IL15

Subcellular Localization：Membrane,Nucleus membrane,Cell surface,Endoplasmic reticulum membrane,Golgi apparatus membrane,Cytoplasmic vesicle membrane,Membrane,Endoplasmic reticulum membrane,Golgi apparatus membrane,Cytoplasmic vesicle membrane,Membrane,Endoplasmic reticulum membrane,Golgi apparatus membrane,Cytoplasmic vesicle membrane,Membrane,Endoplasmic reticulum membrane,Golgi apparatus membrane,Cytoplasmic vesicle membrane,Membrane,Secreted, extracellular space

Expression：
Tissue_Specificity: Expressed in neutrophils (at protein level) (PubMed:15123770). Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus (PubMed:12114302). Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures (PubMed:12114302). Isoforms 1, 3, 4, 5, 6, 7, 8 and 9: Widely expressed (PubMed:10480910, PubMed:8530383)

Isoforms & Post-Translational Modification：Q13261 has 9 isomers: Q13261-1: 28233 Da (predicted); Q13261-3: 24870 Da (predicted); Q13261-4: 26299 Da (predicted); Q13261-5: 22936 Da (predicted); Q13261-6: 20904 Da (predicted); Q13261-7: 18969 Da (predicted); Q13261-8: 17641 Da (predicted); Q13261-9: 15707 Da (predicted); Q13261-10: 24388 Da (predicted).
N-glycosylated and O-glycosylated丨A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (PubMed:15265897)

Subunit：The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG

Synonyms

AA690181 antibody; CD215 antibody; I15RA_HUMAN antibody; IL 15R alpha antibody; IL-15 receptor subunit alpha antibody; IL-15R-alpha antibody; IL-15RA antibody; Il15ra antibody; Interleukin 15 receptor alpha antibody; Interleukin 15 receptor subunit alpha antibody

Documentation

User Guide for Antibodies (1077 KB)