38 Results for "

il-2r-alpha

" in MedChemExpress (MCE) Product Catalog:
Products (38)

38 Results for "il-2r-alpha" in MCE Product Catalog:

Cat. No.: HY-P99410
CAS No.: 879293-15-9
Synonyms: AMG 714; PRV-015

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD) .
loading...
    loading...
Cat. No.: HY-108738
CAS No.: 152923-56-3
Purity:  99.18%
Synonyms: Ro 24-7375
Daclizumab (Ro 24-7375) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab inhibits effector T cell activation, regulatory T cell (Treg) expansion and survival, and activation-induced T-cell apoptosis. Daclizumab increases IL-2 bioavailability to bind to the intermediate-affinity IL-2R (IL-2R-IA), driving the expansion of anti-inflammatory CD56bright natural killer (NK) cells. Daclizumab can be used for multiple sclerosis and cancer research .
loading...
    loading...
Cat. No.: HY-P990281

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) is a rat-derived IgG1 λ type antibody inhibitor, targeting to mouse CD25/IL-2Rα. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can deplete CD25+ T cells. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can be used for the researches of immunology and inflammation, such as atopic dermatitis .
loading...
    loading...
Cat. No.: HY-P99902
CAS No.: 1776942-10-9
Synonyms: FAP-il2v; RO6874281; RG7461

Target:  

Interleukin Related

Research Areas:  

Cancer

Simlukafusp alfa (FAP-IL2v) is an immunocytokine comprising an antibody against fibroblast activation protein α (FAPα) and an IL-2 variant that only binds IL-2Rβγ. Isotype: human IgG1 .
loading...
    loading...
Cat. No.: HY-P991740

Research Areas:  

Cancer

IBI-363 is a PD-1/IL-2 bispecific antibody with functions of blocking the PD-1/PD-L1 pathway and activating the IL-2 pathway. The IL-2 arm of IBI-363 retains affinity for IL-2Rα but attenuates binding ability to IL-2Rβ and IL-2Rγ to reduce toxicity. The PD-1 binding arm of IBI-363 enables PD-1 blockade and selective delivery of IL-2. IBI-363 can be used in cancer research, such as non-small cell lung cancer .
loading...
    loading...
Cat. No.: HY-119424
CAS No.: 515846-21-6
Purity:  98.11%
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (Kd=70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα (Kd=10 nM) .
loading...
    loading...
Cat. No.: HY-P99759
CAS No.: 1622189-43-8
Synonyms: il-15N72D

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Nogapendekin alfa his tag (IL-15N72D) is a blood-brain barrier-permeable IL-2Rβ (CD122) binding enhancer and antitumor agent. Nogapendekin alfa his tag promotes the proliferation and activation of NK cells and CD8 + T cells, enhances cytotoxicity through the expression of granzyme B and perforin, reduces tumor burden, and boosts the activity of bacillus Calmette-Guérin (BCG). Nogapendekin alfa his tag promotes the secretion of proinflammatory cytokines including IL-6, IFN-γ, MCP-1, TNF-α, IL-1α, IL-1β and RANTES, and also stimulates the infiltration of immune cells into lymphoid organs and the tumor microenvironment. Nogapendekin alfa his tag reduces tumor angiogenesis and tumor cell proliferation, and enhances antibody-dependent cell-mediated cytotoxicity of anti-PD-L1 monoclonal antibodies as well as bifunctional fusion proteins targeting PD-L1 and TGF-βR2. Nogapendekin alfa his tag is suitable for research on non-muscle-invasive bladder cancer .
loading...
    loading...
Cat. No.: HY-P1453A
Research Areas:  

Cancer

CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development .
loading...
    loading...
Cat. No.: HY-121743
CAS No.: 193744-04-6
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ro26-4550 is a low micromolar antagonist of IL-2/IL-2Rα binding with an IC50 value of 3 μM .
loading...
    loading...
Cat. No.: HY-P1453
Research Areas:  

Cancer

CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development .
loading...
    loading...
Cat. No.: HY-P99664
CAS No.: 152981-31-2

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Inolimomab is an anti-interleukin-2 receptor (IL-2R) α chain monoclonal antibody. Inolimomab improves the survival rate in the early research of treating acute graft-versus-host disease (aGVHD) .
loading...
    loading...
Cat. No.: HY-P990866

Target:  

Interleukin Related

Research Areas:  

Cancer

Anti-CD25/IL-2Rα Antibody (7G7B6) is an anti-human CD25/IL-2Rα IgG2a monoclonal antibody. Anti-CD25/IL-2Rα Antibody (7G7B6) can inhibit the growth of tumors. Anti-CD25/IL-2Rα Antibody (7G7B6) can be used for research on leukemia. The recommend isotype control of Anti-CD25/IL-2Rα Antibody (7G7B6): Mouse IgG2a kappa, Isotype Control (HY-P99978) .
loading...
    loading...
Cat. No.: HY-P78412
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD25; IDDM10; il-2 R alpha; il2r; il2rA; p55; TCGFR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P705037
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD25; IDDM10; il-2 R alpha; il2r; il2rA; p55; TCGFR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P78092
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD25; IDDM10; il-2 R alpha; il2r; il2rA; p55; TCGFR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-103390
CAS No.: 1217448-66-2
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ro26-4550 TFA is a low micromolar antagonist of IL-2/IL-2Rα binding with an IC50 value of 3 μM .
loading...
    loading...
Cat. No.: HY-P76785
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD25; IDDM10; il-2 R alpha; il2-RA; Interleukin 2 receptor, alpha; TCGFR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P74809
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD25; IDDM10; il-2 R alpha; il2-RA; Interleukin 2 receptor, alpha; TCGFR
Species:  
Rat
Source:  
loading...
    loading...
Cat. No.: HY-P74811
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD25; IDDM10; il-2 R alpha; il2-RA; Interleukin 2 receptor, alpha; TCGFR
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P76786
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD25; IDDM10; il-2 R alpha; il2-RA; Interleukin 2 receptor, alpha; TCGFR
Species:  
Source:  
loading...
    loading...