2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. (R)-Bicalutamide

(R)-Bicalutamide 

Cat. No.: HY-108250 Purity: 99.91%
COA Handling Instructions

(R)-Bicalutamide is the (R)-enantiomer of Bicalutamide (HY-14249). (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer.

For research use only. We do not sell to patients.

(R)-Bicalutamide Chemical Structure

(R)-Bicalutamide Chemical Structure

CAS No. : 113299-40-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 150 In-stock
50 mg USD 530 In-stock
100 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-Bicalutamide:

(R)-Bicalutamide Related Antibodies

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Description

(R)-Bicalutamide is the (R)-enantiomer of Bicalutamide (HY-14249). (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer[1][2].

IC50 & Target

AR[1]
In Vitro

Bicalutamide (HY-14249) is available as a racemic mixture. The R isomer (R-bicalutamide) has an ≈30-fold higher binding affinity to the AR than the S isomer[1].
(R)-bicalutamide (0.02-20 μM) reduces na ve LNCaP cells survival in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-Bicalutamide Related Antibodies

Cell Proliferation Assay[2]

Cell Line: LNCaP cells, LNCaP-Rbic cells
Concentration: 0.02 μM, 0.2 μM, 2 μM, 20 μM
Incubation Time: 144 hours
Result: Reduced naïve LNCaP cells survival in a dose-dependent, with an IC50 value of about 7 μM; exerted a poor antiproliferative effect on LNCaP-Rbic.
In Vivo

(R)-Bicalutamide (10 mg/kg; i.g.; daily; for 4 days) has antitumor efficacy in VCaP xenografts mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 male nude (nu/nu) mice, with VCaP xenografts[3]
Dosage: 10 mg/kg
Administration: Orally gavage, daily, for 4 consecutive weeks
Result: Suppressed tumor growth.
Molecular Weight

430.37

Appearance

Solid

Formula

C18H14F4N2O4S
CAS No.
SMILES

O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)CS(=O)(C2=CC=C(F)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (232.36 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3236 mL 11.6179 mL 23.2358 mL
5 mM 0.4647 mL 2.3236 mL 4.6472 mL
10 mM 0.2324 mL 1.1618 mL 2.3236 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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(R)-Bicalutamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(R)-Bicalutamide113299-40-4Androgen ReceptorantiandrogenprostatecancerantineoplasticmodulatingandrogenreceptorLNCaP cellsInhibitorinhibitorinhibit

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