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Bicalutamide 

Cat. No.: HY-14249 Purity: 99.62%
Handling Instructions

Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

Bicalutamide Chemical Structure

Bicalutamide Chemical Structure

CAS No. : 90357-06-5

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10 mM * 1 mL in DMSO USD 55 In-stock
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500 mg USD 80 In-stock
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1 g USD 100 In-stock
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5 g USD 250 In-stock
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Bicalutamide:

Top Publications Citing Use of Products

    Bicalutamide purchased from MCE. Usage Cited in: Sci Rep. 2017 Jun 8;7(1):3058.

    CXCR7 mRNA in cells treated with 2 µM Bicalutamide (BiC) relative to untreated (UT) cells.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer[1].

    IC50 & Target

    Androgen receptor[1]

    In Vitro

    Bicalutamide competes with androgens for binding AR in in a whole-cell binding-assay (LNCaP/AR(cs) cells), with an IC50 of 160 nM[1].
    Bicalutamide induces proliferation of VCaP cells in a dose-dependent manner, whereas partially antagonizes the effects of R1881 (synthetic androgen)[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Bicalutamide (10 mg/kg; i.g.; daily; for 28 days) exhibits anti-tumor activity in prostate cancer mice model[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Castrate male mice, bearing LNCaP/AR(cs) xenograft tumors[1]
    Dosage: 10 mg/kg
    Administration: Oral gavage, daily, for 28 days
    Result: Inhibited tumors growth.
    Clinical Trial
    Molecular Weight

    430.37

    Formula

    C₁₈H₁₄F₄N₂O₄S

    CAS No.

    90357-06-5

    SMILES

    FC1=CC=C(S(=O)(CC(O)(C(NC2=CC=C(C#N)C(C(F)(F)F)=C2)=O)C)=O)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (116.18 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3236 mL 11.6179 mL 23.2358 mL
    5 mM 0.4647 mL 2.3236 mL 4.6472 mL
    10 mM 0.2324 mL 1.1618 mL 2.3236 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.62%

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    Keywords:

    BicalutamideAndrogen ReceptorAutophagynon-steroidalandrogenreceptorprostate cancercastration-resistantprostatecanceranti-androgenInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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