1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. (R)-(+)-HA-966

(R)-(+)-HA-966 (Synonyms: (+)-HA-966)

Cat. No.: HY-100822
Handling Instructions

(R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain.

For research use only. We do not sell to patients.

(R)-(+)-HA-966 Chemical Structure

(R)-(+)-HA-966 Chemical Structure

CAS No. : 123931-04-4

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine[1][2]. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain[3].

IC50 & Target

glycine site of the NMDA receptor[1][2]

In Vivo

(R)-(+)-HA-966 ((+)-HA-966; 10 mg/kg; IV) significantly attenuates the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA (125, 250, 500, and 1000 mg/kg; i.v.)[3].
(+)-HA-966 (30, 100 mg/kg; IP) dose-dependently blocks the enhancement of dopamine synthesis induced in the nucleus accumbens by amphetamine, but is without effect on the increase in dopamine synthesis in the striatum in male BKTO mice (20-30g)[1].

Animal Model: Sprague-Dawley rats (11 to 12 weeks old)[3]
Dosage: 10 mg/kg
Administration: IV
Result: Significantly attenuated the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA.
Molecular Weight

116.12

Formula

C₄H₈N₂O₂

CAS No.

123931-04-4

SMILES

O=C1N(O)CC[[email protected]]1N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(R)-(+)-HA-966(+)-HA-966iGluRIonotropic glutamate receptorsglycinesiteN-methyl-D-aspartateNMDAmesolimbicdopaminesystemamphetamineblood-brainbarrierneuropathicacutepainInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
(R)-(+)-HA-966
Cat. No.:
HY-100822
Quantity:
MCE Japan Authorized Agent: