2. (R)-(+)-HA-966

(R)-(+)-HA-966  (Synonyms: (+)-HA-966)

Cat. No.: HY-100822 Purity: 98.85%
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(R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain.

For research use only. We do not sell to patients.

(R)-(+)-HA-966 Chemical Structure

(R)-(+)-HA-966 Chemical Structure

CAS No. : 123931-04-4

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(R)-(+)-HA-966 Related Antibodies

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Description

(R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine[1][2]. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain[3].

IC50 & Target

glycine site of the NMDA receptor[1][2]
In Vivo

(R)-(+)-HA-966 ((+)-HA-966; 10 mg/kg; IV) significantly attenuates the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA (125, 250, 500, and 1000 mg/kg; i.v.)[3].
(+)-HA-966 (30, 100 mg/kg; IP) dose-dependently blocks the enhancement of dopamine synthesis induced in the nucleus accumbens by amphetamine, but is without effect on the increase in dopamine synthesis in the striatum in male BKTO mice (20-30g)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (11 to 12 weeks old)[3]
Dosage: 10 mg/kg
Administration: IV
Result: Significantly attenuated the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA.
Molecular Weight

116.12

Formula

C4H8N2O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N(O)CC[C@H]1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (861.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.6118 mL 43.0589 mL 86.1178 mL
5 mM 1.7224 mL 8.6118 mL 17.2236 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 8.6118 mL 43.0589 mL 86.1178 mL 215.2945 mL
5 mM 1.7224 mL 8.6118 mL 17.2236 mL 43.0589 mL
10 mM 0.8612 mL 4.3059 mL 8.6118 mL 21.5295 mL
15 mM 0.5741 mL 2.8706 mL 5.7412 mL 14.3530 mL
20 mM 0.4306 mL 2.1529 mL 4.3059 mL 10.7647 mL
25 mM 0.3445 mL 1.7224 mL 3.4447 mL 8.6118 mL
30 mM 0.2871 mL 1.4353 mL 2.8706 mL 7.1765 mL
40 mM 0.2153 mL 1.0765 mL 2.1529 mL 5.3824 mL
50 mM 0.1722 mL 0.8612 mL 1.7224 mL 4.3059 mL
60 mM 0.1435 mL 0.7176 mL 1.4353 mL 3.5882 mL
80 mM 0.1076 mL 0.5382 mL 1.0765 mL 2.6912 mL
100 mM 0.0861 mL 0.4306 mL 0.8612 mL 2.1529 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-(+)-HA-966123931-04-4(+)-HA-966Inhibitorinhibitorinhibit

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