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Ro5-3335 

Cat. No.: HY-108470
Handling Instructions

Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation.

For research use only. We do not sell to patients.

Ro5-3335 Chemical Structure

Ro5-3335 Chemical Structure

CAS No. : 30195-30-3

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Description

Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation[1].

IC50 & Target

RUNX1-CBFβ interaction[1]

In Vitro

Ro5-3335 has antiproliferative activity against human CBF leukemia cell lines, with IC50s of 1.1 μM, 21.7 μM and 17.3 μM for ME-1, Kasumi-1 and REH, respectively[1].
Ro5-3335 inhibits definitive hematopoiesis in zebrafish embryos[1].
Ro5-3335 does not completely break apart RUNX1-CBFβ interaction, but changes the conformation of their complex or increases the distance between RUNX1 and CBFβ in the complex[1].

In Vivo

Ro5-3335 is identified as an inhibitor of RUNX1–CBFβ function in zebrafish models[1].
Ro5-3335 rescues preleukemic phenotype in a RUNX1-ETO transgenic zebrafish[1].
Ro5-3335 (300 mg/kg/d; p.o; for 30 days) reduces leukemia burden in a mouse CBFB-MYH11 leukemia model[1].

Animal Model: C57BL/6 mice (leukemic model)[1]
Dosage: 300 mg/kg
Administration: Oral administration; daily; for 30 days
Result: Reduced the number of c-kit+ cells in the transplanted mice and leukemic cell infiltration in the livers, bone marrow and spleen.
Molecular Weight

259.69

Formula

C₁₃H₁₀ClN₃O

CAS No.

30195-30-3

SMILES

O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CN3)=NC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ro5-3335OtherscorebindingfactorCBFleukemiaRUNX1CBFβRUNX1-CBFBinteractionInhibitorinhibitorinhibit

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