Cat. No.: HY-B1309

Metacetamol

(Synonyms: AMAP)

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Metacetamol (AMAP) is an analog of Acetaminophen (HY-66005). Metacetamol induces dose-dependent necrosis in primary hepatocytes via glutathione depletion, mitochondrial damage, and formation of mitochondrial protein adducts. Metacetamol derivatives act as anticancer and antibacterial agents. Metacetamol can be used in studies related to breast cancer, bacterial infections, and fungal infections (candidiasis).

For research use only. We do not sell to patients.

Purity: 99.94%
CAS No.: 621-42-1
Formula: C₈H₉NO₂
Molecular Weight:151.16

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Metacetamol Chemical Structure

CAS No.: 621-42-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	GI₅₀	5338 μM Compound: 6b	Cytotoxicity against mouse RAW264.7 cells assessed as growth inhibition after 48 hrs by trypan blue assay Cytotoxicity against mouse RAW264.7 cells assessed as growth inhibition after 48 hrs by trypan blue assay	10.1039/C3MD00251A
Vero C1008	IC₅₀	>2.0 × 10⁵M Compound: COVC-0141286463	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	10.6019/CHEMBL4651402

In Vitro

Metacetamol (AMAP) (5-20 mM; 24-48 h) induces dose-dependent necrotic cell death and glutathione depletion in primary hepatocytes, with significant cytotoxicity observed at concentrations of 5 mM, 10 mM, and 20 mM after 48 h of incubation^[1].
Metacetamol (AMAP) at concentrations of 5-20 mM induces dose-dependent mitochondrial dysfunction in primary hepatocytes^[1].
Metacetamol (AMAP) (6-24 h) induces significant mitochondrial protein adduct formation in primary hepatocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 621-42-1
Appearance Solid
Molecular Weight 151.16
Formula C₈H₉NO₂
Color Off-white to light brown
SMILES

CC(NC1=CC=CC(O)=C1)=O
Synonyms

AMAP
Structure Classification
- Phenols
- Monophenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (330.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.6155 mL

33.0775 mL

66.1551 mL

5 mM

1.3231 mL

6.6155 mL

13.2310 mL

10 mM

0.6616 mL

3.3078 mL

6.6155 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xie Y, et al. Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes. Toxicol Appl Pharmacol. 2015;289(2):213-222. [Content Brief]

[2]. Şenkardeş S, et al. Synthesis and Evaluation of Novel Metacetamol Derivatives with Hydrazone Moiety as Anticancer and Antimicrobial Agents. Chem Biodivers. 2023;20(8):e202300766. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.6155 mL	33.0775 mL	66.1551 mL	165.3877 mL
	5 mM	1.3231 mL	6.6155 mL	13.2310 mL	33.0775 mL
	10 mM	0.6616 mL	3.3078 mL	6.6155 mL	16.5388 mL
	15 mM	0.4410 mL	2.2052 mL	4.4103 mL	11.0258 mL
	20 mM	0.3308 mL	1.6539 mL	3.3078 mL	8.2694 mL
	25 mM	0.2646 mL	1.3231 mL	2.6462 mL	6.6155 mL
	30 mM	0.2205 mL	1.1026 mL	2.2052 mL	5.5129 mL
	40 mM	0.1654 mL	0.8269 mL	1.6539 mL	4.1347 mL
	50 mM	0.1323 mL	0.6616 mL	1.3231 mL	3.3078 mL
	60 mM	0.1103 mL	0.5513 mL	1.1026 mL	2.7565 mL
	80 mM	0.0827 mL	0.4135 mL	0.8269 mL	2.0673 mL
	100 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.6539 mL

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Metacetamol

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Chemical Information

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References

Help & FAQs

Complete Stock Solution Preparation Table

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