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Results for "

18:1 PI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PI3K (2) Akt (1) Biochemical Assay Reagents (6) Endogenous Metabolite (1) HIV (1) Isotope-Labeled Compounds (1) Reverse Transcriptase (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (7) Neurological Disease (1)
Oligonucleotides:	Phospholipids (10)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: PI4K PI5P4K PI3K PI4P5K Glucose-6-Phosphate Isomerase (GPI)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100355

C18-Ceramide (d18:1/18:0) C18-Ceramide	Endogenous Metabolite	Neurological Disease Cancer
C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology .

HY-NP181

Testosterone/BSA 1 Publications Verification	Biochemical Assay Reagents	Others
Testosterone/BSA, a conjugate of Testosterone (HY-113415) and bovine serum albumin (BSA), acts as a nuclear transporter and cytoplasmic accumulator. Testosterone/BSA can enter the nuclei of rat testicular spermatocytes, spermatids and rat liver endothelial cells, while the antigenicity of BSA remains intact. Testosterone/BSA accumulates in the cytoplasm of rat hepatocytes in granular form. Testosterone/BSA can be used to investigate the membrane-initiated or non-genomic activities of steroid hormones .

HY-157704

18:1 PI(3)P	Biochemical Assay Reagents
18:1 PI(3)P is a kind of biochemical reagent.

HY-117163

FzM1.8 1 Publications Verification	Wnt β-catenin	Cancer
FzM1.8, derives from FzM1, is an allosteric agonist of FZD4 with pEC₅₀ of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K .

HY-157706

*PI(3,4)P2 (18:1) ammonium salt*	PI3K	Cardiovascular Disease Metabolic Disease Cancer
PI(3,4)P2 (18:1) ammonium salt is a phosphatidylinositol 3 kinase (PI3K) activator. PI(3,4)P2 (18:1) ammonium salt is a polyphosphorylated phosphatidylinositol that promotes the activation of AKT (protein kinase B) by activating *PI3K, which affects cell metabolism, growth and survival. PI(3,4)P2 (18:1) ammonium salt is also involved in regulating dynamic changes in the cytoskeleton, affecting cell morphology and movement. PI(3,4)P2 (18:1*) ammonium salt can be used in research on the development of cancer, diabetes and cardiovascular disease .

HY-157703

18:1 PI(4,5)P2 1,2-Dioleoyl-sn-glycero-3-phospho-1′-myo-inositol-4′,5′-bisphosphate ammonium	Biochemical Assay Reagents
18:1 PI(4,5)P2 (1,2-Dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium)) is a kind of biochemical reagent.

HY-178923

NNRT-IN-14	HIV Reverse Transcriptase	Infection
NNRT-IN-14 is an HIV-1 reverse transcriptase inhibitor (IC₅₀ = 0.175 µM). NNRT-IN-14 can form hydrogen bonds with LYS101, PRO225, and PHE227, and π–π stacking with TYR181 and TRP229. NNRT-IN-14 can be used for the study of HIV .

HY-157707

18:1 PI(3,4,5)P3	Biochemical Assay Reagents
18:1 PI(3,4,5)P3 is a biochemical reagent .

HY-146824S

*17:0-18:1* PI-d5 ammonium**	Isotope-Labeled Compounds	Others
17:0-18:1 PI-d₅ (ammonium) is deuterium labeled 17:0-18:1 PI (ammonium).

HY-N15977

18:1-6:0 Biotin PI(3,5)P2 ammonium）	Biochemical Assay Reagents	Others
18:1-6:0 Biotin PI(3,5)P2 ammonium is a biotinylated lipid.

HY-10109A

AS-605240 potassium	PI3K Akt	Inflammation/Immunology
AS-605240 (potassium) is an orally active PI3Kγ inhibitor (IC₅₀: 8 nM; K_i: 7.8 nM). AS-605240 (potassium) inhibits MCP-1- and CSF1-induced PKB phosphorylation (IC₅₀ values are 0.181 and 0.550 µM, respectively). AS-605240 (potassium) reduces neutrophil recruitment in RANTES (CCL5)- and thioglycolate-induced peritonitis mouse models (EC₅₀ values are 9.1 and 10 mg/kg, respectively). AS-605240 (potassium) ameliorates αCII-IA-induced arthritis in mice .

HY-N16001

18:1-6:0 Biotin PI(4,5)P2 triammonium	Biochemical Assay Reagents	Others
18:1-6:0 Biotin PI(4,5)P2 triammonium is a biotinylated lipid.

Cat. No.	Product Name

HY-L181

Bioactive Compound Library Max	29,173 compounds
Bioactive small molecules are important sources of lead compounds and effective tools for drug screening. Because the target of active small molecules is clear, it is conducive to the study of mechanism. In addition, due to the large structural differences between the individual active molecules, it is easier to obtain a greater variety of lead compounds. MCE integrates the Bioactive Compound Library (HY-L001) and Novel Bioactive Compound Library (HY-L111) to form the Bioactive Compound Library Max. Bioactive Compound Library Max contains novel active small molecules, molecules that have entered the clinical stage and the market, and small molecules that have been verified by cell experiments or biochemical experiments, which fundamentally expands the number of compound libraries in the library and improves the structural diversity, and is an effective tool to start drug screening and mechanism research. MCE can provide a library of 29,173 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

Bioactive Compound Library Max

29,173 compounds

Bioactive small molecules are important sources of lead compounds and effective tools for drug screening. Because the target of active small molecules is clear, it is conducive to the study of mechanism. In addition, due to the large structural differences between the individual active molecules, it is easier to obtain a greater variety of lead compounds.

MCE integrates the Bioactive Compound Library (HY-L001) and Novel Bioactive Compound Library (HY-L111) to form the Bioactive Compound Library Max. Bioactive Compound Library Max contains novel active small molecules, molecules that have entered the clinical stage and the market, and small molecules that have been verified by cell experiments or biochemical experiments, which fundamentally expands the number of compound libraries in the library and improves the structural diversity, and is an effective tool to start drug screening and mechanism research.

MCE can provide a library of 29,173 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

HY-L074

Anti-Breast Cancer Compound Library	3,181 compounds
Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC). Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer. MCE supplies a unique collection of 3,181 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Anti-Breast Cancer Compound Library

3,181 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 3,181 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Cat. No.	Product Name	Type

HY-NP181

Testosterone/BSA 1 Publications Verification	Biochemical Assay Reagents
Testosterone/BSA, a conjugate of Testosterone (HY-113415) and bovine serum albumin (BSA), acts as a nuclear transporter and cytoplasmic accumulator. Testosterone/BSA can enter the nuclei of rat testicular spermatocytes, spermatids and rat liver endothelial cells, while the antigenicity of BSA remains intact. Testosterone/BSA accumulates in the cytoplasm of rat hepatocytes in granular form. Testosterone/BSA can be used to investigate the membrane-initiated or non-genomic activities of steroid hormones .

Testosterone/BSA

1 Publications Verification

Biochemical Assay Reagents

Testosterone/BSA, a conjugate of Testosterone (HY-113415) and bovine serum albumin (BSA), acts as a nuclear transporter and cytoplasmic accumulator. Testosterone/BSA can enter the nuclei of rat testicular spermatocytes, spermatids and rat liver endothelial cells, while the antigenicity of BSA remains intact. Testosterone/BSA accumulates in the cytoplasm of rat hepatocytes in granular form. Testosterone/BSA can be used to investigate the membrane-initiated or non-genomic activities of steroid hormones .

HY-157704

18:1 PI(3)P	Biochemical Assay Reagents
18:1 PI(3)P is a kind of biochemical reagent.

HY-157703

18:1 PI(4,5)P2 1,2-Dioleoyl-sn-glycero-3-phospho-1′-myo-inositol-4′,5′-bisphosphate ammonium	Biochemical Assay Reagents
18:1 PI(4,5)P2 (1,2-Dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium)) is a kind of biochemical reagent.

HY-157707

18:1 PI(3,4,5)P3	Biochemical Assay Reagents
18:1 PI(3,4,5)P3 is a biochemical reagent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100355

C18-Ceramide (d18:1/18:0) C18-Ceramide	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology .

HY-N15977

18:1-6:0 Biotin PI(3,5)P2 ammonium）	Lipid	Biochemical Assay Reagents
18:1-6:0 Biotin PI(3,5)P2 ammonium is a biotinylated lipid.

HY-N16001

18:1-6:0 Biotin PI(4,5)P2 triammonium	Lipid	Biochemical Assay Reagents
18:1-6:0 Biotin PI(4,5)P2 triammonium is a biotinylated lipid.

Cat. No.	Product Name	Chemical Structure

HY-146824S

*17:0-18:1* PI-d5 ammonium**
17:0-18:1 PI-d₅ (ammonium) is deuterium labeled 17:0-18:1 PI (ammonium).

Cat. No.	Product Name		Classification

HY-157706

*PI(3,4)P2 (18:1) ammonium salt*		Phospholipids
PI(3,4)P2 (18:1) ammonium salt is a phosphatidylinositol 3 kinase (PI3K) activator. PI(3,4)P2 (18:1) ammonium salt is a polyphosphorylated phosphatidylinositol that promotes the activation of AKT (protein kinase B) by activating *PI3K, which affects cell metabolism, growth and survival. PI(3,4)P2 (18:1) ammonium salt is also involved in regulating dynamic changes in the cytoskeleton, affecting cell morphology and movement. PI(3,4)P2 (18:1*) ammonium salt can be used in research on the development of cancer, diabetes and cardiovascular disease .

HY-157703

18:1 PI(4,5)P2 1,2-Dioleoyl-sn-glycero-3-phospho-1′-myo-inositol-4′,5′-bisphosphate ammonium		Phospholipids
18:1 PI(4,5)P2 (1,2-Dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium)) is a kind of biochemical reagent.

HY-157701

18:1 PI(4)P		Phospholipids
18:1 PI(4)P is a phosphoinositide. Phosphoinositides (PI) are similar to other phospholipids, but the head group is the cyclic myo-inositol.

HY-W725832

18:1 Lyso PI ammonium PI(18:1(9Z)/0:0) ammonium		Phospholipids
18:1 Lyso PI (ammonium) is a lysophosphatidylinositol.

HY-157707

18:1 PI(3,4,5)P3		Phospholipids
18:1 PI(3,4,5)P3 is a biochemical reagent .

HY-157709

18:1 PI ammonium DOPI(18:1(9Z)/18:1(9Z)) ammonium		Phospholipids
18:1 PI (ammonium) is a phosphoinositide. Phosphoinositides (PI) are similar to other phospholipids, but the head group is the cyclic myo-inositol.

HY-157705

18:1 PI(3,5)P2 triammonium PIP2[3',5'](18:1(9Z)/18:1(9Z)) triammonium		Phospholipids
18:1 PI(3,5)P2 (triammonium) is a phosphoinositide. Phosphoinositides (PI) are similar to other phospholipids, but the head group is the cyclic myo-inositol.

HY-W725804

*15:0-18:1* PI ammonium**		Phospholipids
15:0-18:1 PI (ammonium) is a phosphoinositide. Phosphoinositides (PI) are similar to other phospholipids, but the head group is the cyclic myo-inositol.

HY-157621

*16:0-18:1* PI(4)P ammonium**		Phospholipids
16:0-18:1 PI(4)P (ammonium) is a phosphoinositide. Phosphoinositides (PI) are similar to other phospholipids, but the head group is the cyclic myo-inositol.

HY-157619

*16:0-18:1* PI ammonium** 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoinositol ammonium		Phospholipids
16:0-18:1 PI (ammonium) is a phosphoinositide. Phosphoinositides (PI) are similar to other phospholipids, but the head group is the cyclic myo-inositol.

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18:1 PI

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products