2304-81-6
Chemical Structure
C18-Ceramide (d18:1/18:0)
Synonym(s): C18-Ceramide
- CAS No.: 2304-81-6
- Formula:C36H71NO3
- Molecular Weight:565.95
IUPAC Name: N-((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl)stearamide
InChIKey: VODZWWMEJITOND-NXCSZAMKSA-N
SMILES: CCCCCCCCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
Biological Activity: C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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C18-Ceramide (d18:1/18:0) | 99.95% | C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology. | ||||||||||||||||||||
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C18-Ceramide (Standard) | ≥98% | C18-Ceramide (Standard) is the analytical standard of C18-Ceramide. This product is intended for research and analytical applications. C18-Ceramide can promote exocytosis of glutamate from damaged neurons. C18-Ceramide promotes cell death in glioma cells. Ceramides is involved in diverse cellular functions, such as differentiation, cell cycle progression, cell-cell adhesion, senescence, and apoptosis. | ||||||||||||||||||||
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C18-Ceramide-d3 | C18-Ceramide-d3 is the deuterium labeled C18-Ceramide. | |||||||||||||||||||||
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C18-Ceramide-d7 | 99.0% | C18-Ceramide-d7 is deuterium labeled C18-Ceramide. | ||||||||||||||||||||
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C18-Ceramide-13C2,d2 | C18-Ceramide-13C2,d2 is a deuterated labeled C18-Ceramide-13C2,d2. | |||||||||||||||||||||
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- [1]. Tang N, et al. Differential effects of ceramide species on exocytosis in rat PC12 cells. Exp Brain Res. 2007 Nov;183(2):241-7. [Content Brief]
- [2]. Wang Z, et al. Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma. Oncotarget. 2017 Oct 23;8(61):104022-104036. [Content Brief]
