1 Result for "

2-Methoxyjuglone

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "2-Methoxyjuglone" in MCE Product Catalog:

2-Methoxyjuglone
2-Methoxyjuglone
0 Images
Cat. No.: HY-N17440
CAS No.: 15127-94-3
Category:  

Quinones Juglandaceae Phenols Plants Juglans mandshurica Naphthalene Quinones

Target:  

Apoptosis Caspase Bcl-2 Family DNA/RNA Synthesis Bacterial Fungal

2-Methoxyjuglone, a naphthoquinone, is an apoptosis inducer. 2-Methoxyjuglone activates caspase-9 and caspase-3 via the mitochondrial cytochrome c-dependent intrinsic apoptosis cascade. 2-Methoxyjuglone increases pro-apoptotic Bax levels, decreases anti-apoptotic Bcl-2 levels, and promotes mitochondrial cytochrome c release. 2-Methoxyjuglone induces apoptosis morphological features, early apoptosis, S-phase and G2/M-phase cell cycle arrest, and DNA double-strand breaks. 2-Methoxyjuglone exerts activity against Gram-positive bacteria, pathogenic fungi, and phytopathogenic fungi. 2-Methoxyjuglone can be used for the research of hepatocellular carcinoma, osteosarcoma, colon adenocarcinoma, breast cancer, fungal infection, bacterial infection [2] .
loading...
    loading...
View All Sizes
Assay Types