1 Result for "

3371-85-5

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "3371-85-5" in MCE Product Catalog:

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Voacamine
Voacamine
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Cat. No.: HY-N6932
CAS No.: 3371-85-5
Category:  

Alkaloids other families Metabolic Disease Plants Disease Research Fields Indole Alkaloids

Target:  

Cannabinoid Receptor P-glycoprotein PI3K Akt mTOR Apoptosis Autophagy EGFR

Voacamine is an indole alkaloid with cannabinoid 1 (CB1) antagonistic activity. Voacamine can inhibit nuclear translocation. Voacamine is effective in enhancing the effect of Doxorubicin (HY-15142A) as it interferes with the P-glycoprotein (P-gp) function. Voacamine promotes apoptosis-independent autophagic cell death in human osteosarcoma cells. Voacamine activates mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Voacamine inhibits EGFR to exert oncogenic activity against colorectal cancer .
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