68 Results for "

41BB

" in MedChemExpress (MCE) Product Catalog:
Products (68)

68 Results for "41BB" in MCE Product Catalog:

Acasunlimab
Acasunlimab
0 Images
Cat. No.: HY-P99419
CAS No.: 2253937-12-9
Synonyms: GEN1046

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer .
Nesfrotamig
Nesfrotamig
0 Images
Cat. No.: HY-P991149
CAS No.: 2966936-23-0
Synonyms: YH32367; ABL105

Target:  

TNF Receptor

Research Areas:  

Cancer

Nesfrotamig (YH32367; ABL105) is a bispecific activator targeting HER2 and 4-1BB. The Kd values of Nesfrotamig for human HER2 and human 4-1BB are 0.48 nM and 3.36 nM, respectively. By blocking tumor cell growth signals, activating HER2-dependent local 4-1BB in tumors to maintain T cell survival, and inducing NK cell-mediated antibody-dependent cellular cytotoxicity, Nesfrotamig enhances the cytotoxicity and tumor infiltration ability of immune cells. Nesfrotamig promotes the generation of tumor-specific memory T cells, drives T cell-mediated tumor lysis, exhibits significant anti-tumor efficacy against both HER2-positive and HER2-low-expressing tumors, and shows synergistic activity when combined with anti-PD-1 antibodies. In cynomolgus monkey studies, Nesfrotamig demonstrates good safety and is suitable for research related to HER2-positive and HER2-low-expressing tumors .
Tecaginlimab
Tecaginlimab
0 Images
Cat. No.: HY-P99572
CAS No.: 2253891-70-0
Synonyms: BNT-312; DuoBody-CD40x-4-1BB; GEN1042

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity .
Cinrebafusp alfa
Cinrebafusp alfa
0 Images
Cat. No.: HY-P99605
CAS No.: 2218515-90-1
Synonyms: PRS 343

Target:  

EGFR TNF Receptor

Research Areas:  

Cancer

Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research .
Englumafusp alfa
Englumafusp alfa
0 Images
Cat. No.: HY-P990017
CAS No.: 2417199-08-5
Synonyms: CD19-4-1BBL; RO7227166; RG6076

Target:  

CD19

Research Areas:  

Cancer

Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion construct comprised of a CD19-specific antibody domain fused to a trimerized extracellular domains of human 41BBL. Englumafusp alfa promotes CD19-specific 4-1BB cross-linking on the surface of T and NK cells .
Emfizatamab
Emfizatamab
0 Images
Cat. No.: HY-P99914
CAS No.: 2559704-23-1
Synonyms: GNC-038

Target:  

PD-1/PD-L1 CD19 TNF Receptor CD3 Interleukin Related IFNAR

Research Areas:  

Inflammation/Immunology Cancer

Emfizatamab (GNC-038) is a monoclonal antibody against CD19/CD3E/TNFRSF9/PD-L1. Emfizatamab exhibits antitumor activity, being capable of activating CD3 and 4-1BB signals on T cells, as well as targeting the high expression of CD19 or PD-L1 on tumor cells. Emfizatamab functions as a CD19-specific T cell engager by mediating direct antitumor activity. Emfizatamab can also overcome the inhibition of T cells by PD-L1. Emfizatamab can be used in the research of tumors such as R/R non-Hodgkin lymphoma or acute lymphoblastic leukemia .
Enristomig
Enristomig
0 Images
Cat. No.: HY-P990738
CAS No.: 2539845-73-1
Synonyms: ES-101; INBRX-105

Target:  

TNF Receptor PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Enristomig (ES-101) is a multispecific antibody. Enristomig is both a PD-L1 antagonist and a conditional agonist of 4-1BB. Enristomig can be used for research on PD-L1 expressing tumors .
Givastomig
Givastomig
0 Images
Cat. No.: HY-P990742
CAS No.: 2762499-30-7
Synonyms: TJ-CD4B; ABL111; TJ033721

Target:  

TNF Receptor Claudin

Research Areas:  

Inflammation/Immunology Cancer

Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma .
Evunzekibart
Evunzekibart
0 Images
Cat. No.: HY-P990067
CAS No.: 2639688-77-8
Synonyms: ATOR-1017

Target:  

TNF Receptor

Research Areas:  

Cancer

Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody. Evunzekibart can be used as monotherapy or in combination with anti-PD1 to exert anticancer activity.
Nebratamig
Nebratamig
0 Images
Cat. No.: HY-P991209
CAS No.: 2694723-68-5
Synonyms: GNC-035

Target:  

ROR CD3 PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Nebratamig (GNC-035) is an anti-ROR1/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody with potential immunostimulatory and antineoplastic activities .
Xirestomig
Xirestomig
0 Images
Cat. No.: HY-P990778
CAS No.: 2756879-35-1
Synonyms: ATG-101

Target:  

TNF Receptor PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Xirestomig (ATG-101) is a tetravalent "2+2″ PD-L1×4-1BB bispecific antibody. Xirestomig binds PD-L1 and 4-1BB concurrently, with a greater affinity for PD-L1, and potently activated 4-1BB+ T cells when cross-linked with PD-L1-positive cells. Xirestomig activates exhausted T cells upon PD-L1 binding. Xirestomig displays potent antitumor activity in numerous in vivo tumor models, including those resistant or refractory to immune checkpoint inhibitors (ICIs) .
ADG-106
ADG-106
0 Images
Cat. No.: HY-P991070

Target:  

TNF Receptor

Research Areas:  

Cancer

ADG-106 is a fully human agonistic monoclonal IgG4 antibody against CD137 (4-1BB). ADG-106 has the mechanism to activate CD137 via strong FcγRIIB-mediated crosslinking while antagonizing CD137 ligands. The isotype control for ADG-106 can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1)
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1)
0 Images
Cat. No.: HY-P990304

Target:  

TNF Receptor

Research Areas:  

Infection Inflammation/Immunology Cancer

Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) is a rat-derived IgG2a κ antibody inhibitor, targeting to mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can block 4-1BB ligand (4-1BBL) and inhibit CD4 + and CD8 + T cells. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology, such as MC38 tumor, lymphocytic choriomeningitis virus (LCMV) infection and herpetic stromal keratitis (HSK) .
Ragistomig
Ragistomig
0 Images
Cat. No.: HY-P990757
CAS No.: 2763222-58-6
Synonyms: ABL503, TJ-L14B

Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology

Ragistomig can simultaneously target programmed death-ligand 1 (PD-L1) and the 4-1BB receptor. Ragistomig elicits potent anti-tumor T-cell responses without inducing significant toxicity. Ragistomig is applicable for tumor research .
ALG.APV-527
ALG.APV-527
0 Images
Cat. No.: HY-P991095
Synonyms: APV-527; ATOR-1016

Target:  

Transmembrane Glycoprotein

Research Areas:  

Cancer

ALG.APV-527 (APV-527) is a bispecific 4-1BB (CD137) and 5T4 antibody. ALG.APV-527 is designed to activate 4-1BB on T and natural killer (NK) cells only when simultaneously bound to 5T4-expressing tumor cells. ALG.APV-527 has a potent antitumor activity .
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)
0 Images
Cat. No.: HY-P990809

Target:  

TNF Receptor

Research Areas:  

Infection Inflammation/Immunology Cancer

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic mouse-derived IgG2a κ antibody, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection .
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a)
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a)
0 Images
Cat. No.: HY-P990304A

Target:  

TNF Receptor

Research Areas:  

Infection Inflammation/Immunology Cancer

Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) is a mouse-derived IgG2a κ antibody inhibitor that targets mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) is a chimeric version of the original TKS-1 antibody (HY-P990304). The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) reacts with mouse 4-1BB ligand (4-1BBL). Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) can be used for the researches of cancer, infection, inflammation and immunology.
Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1)
Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1)
0 Images
Cat. No.: HY-P990304B

Target:  

TNF Receptor

Research Areas:  

Infection Inflammation/Immunology Cancer

Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) is a mouse-derived IgG1 κ antibody inhibitor that targets mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) is a chimeric version of the original TKS-1 antibody (HY-P990304). The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG1. Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) contains a D265A mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) reacts with mouse 4-1BB ligand (4-1BBL). Anti-Mouse 4-1BBL/CD137L (D265A) Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology.
Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1)
Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1)
0 Images
Cat. No.: HY-P990304C

Target:  

TNF Receptor

Research Areas:  

Infection Others Inflammation/Immunology Cancer

Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) is a mouse-derived IgG2a κ antibody inhibitor that targets mouse 4-1BBL/CD137L.Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) is a chimeric version of the original TKS-1 antibody (HY-P990304). The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) reacts with mouse 4-1BB ligand (4-1BBL). Anti-Mouse 4-1BBL/CD137L (LALA-PG) Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology.
4-1BB/TNFRSF9 Protein, Human (HEK293, Fc-Avi)
4-1BB/TNFRSF9 Protein, Human (HEK293, Fc-Avi)
0 Images
Cat. No.: HY-P78386
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD137; TNFRSF9; 4-1BB ligand receptor; 41BB; 4-1BB; CDw137; FLJ43501; ILA; T cell antigen ILA
Species:  
Human
Source:  
HEK293
Assay Types