2417199-08-5
2417199-08-5
Chemical Structure
Englumafusp alfa
Synonym(s): CD19-4-1BBL; RO7227166; RG6076
- CAS No.: 2417199-08-5
- Molecular Weight:(179.19 kDa)
SMILES: [Englumafusp alfa]
Biological Activity: Englumafusp alfa (CD19-4-1BBL) is a 4-1BB ligand fusion protein targeting CD19. Englumafusp alfa binds human 4-1BB and CD19, crosslinks T cells into trimeric complexes, and resists internalization upon binding to CD19-positive B cells. Englumafusp alfa induces interferon-γ in activated peripheral blood mononuclear cells and promotes immune synapse formation with CD20-TCB. Englumafusp alfa can be used in research on relapsed or refractory B-cell non-Hodgkin lymphoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Englumafusp alfa | 99.93% | Englumafusp alfa (CD19-4-1BBL) is a 4-1BB ligand fusion protein targeting CD19. Englumafusp alfa binds human 4-1BB and CD19, crosslinks T cells into trimeric complexes, and resists internalization upon binding to CD19-positive B cells. Englumafusp alfa induces interferon-γ in activated peripheral blood mononuclear cells and promotes immune synapse formation with CD20-TCB. Englumafusp alfa can be used in research on relapsed or refractory B-cell non-Hodgkin lymphoma. | ||||||||||||||||||||
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References
- [1]. Jamois C, et al. Integrated Quantitative Clinical Pharmacology Analysis Identifies Optimal Englumafusp Alfa Dose Range for Proof-of-Concept Study with Glofitamab in Second-Line Large B-Cell Lymphoma Patients. Blood. 2024;144(Suppl 1):4180-4181.
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[2]. Claus C, et al. Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy. Sci Transl Med. 2019 Jun 12;11(496):eaav5989.
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