1. Apoptosis
  2. TNF Receptor
  3. Tecaginlimab

Tecaginlimab  (Synonyms: BNT-312; DuoBody-CD40x-4-1BB; GEN1042)

Cat. No.: HY-P99572

Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity.

For research use only. We do not sell to patients.

Tecaginlimab Chemical Structure

Tecaginlimab Chemical Structure

CAS No. : 2253891-70-0

Size Stock
1 mg Get quote
5 mg Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity[1].

IC50 & Target[1]

CD40

 

4-1BB

 

In Vitro

Tecaginlimab binds to recombinant human CD40 and 4-1BB with affinities of 1.0 nM and 0.17 nM, respectively[1].
Tecaginlimab (0.001-1 µg/mL; 5 d) induces dendritic cell (DC) maturation in vitro[1].
Tecaginlimab (0.2 µg/mL; 10-15 d) enhances T-cell activation in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tecaginlimab (0.0008-0.2 µg/mL; 4 d) enhances tumor-infiltrating lymphocyte expansion ex vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS No.
SMILES

[Tecaginlimab]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Tecaginlimab Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tecaginlimab
Cat. No.:
HY-P99572
Quantity:
MCE Japan Authorized Agent: