Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1)
Based on 1 Customer Validation
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) is a rat-derived IgG2a κ antibody inhibitor, targeting to mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can block 4-1BB ligand (4-1BBL) and inhibit CD4+ and CD8+ T cells. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology, such as MC38 tumor, lymphocytic choriomeningitis virus (LCMV) infection and herpetic stromal keratitis (HSK).
For research use only. We do not sell to patients.
- Purity : ≥95.0%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
4-1BBL/CD137L
In Vitro
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (5 μg/mL or 50 μg/mL, 3 days) inhibits proliferation of both CD4+ and CD8+ T cells in response to allogeneic antigen presenting cells and reduces cytotoxicity against host alloantigen in Balb/c antigen presenting cells stimulated normal C57BL/6 T cell[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (200 μg, i.p., at days 0, 3, 6 and 8) inhibits the development of HSK in HSV-1 RE strain-infected herpetic stromal keratitis (HSK) mice[2].
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (200 μg, i.p., at days 0, 2 and 4) prolongs graft survival in Balb/c cardiac grafted C57BL/6 mice[3].
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (100 μg/25g, i.p., daily before applying IMQ) alleviates inflammation in imiquimod (IMQ) (HY-B0180)-induced psoriasis mice[4].
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (100 μg, i.p., at days 0 and 2) suppresses tumor growth companied with 3H3 (HY-P99119) antibody in MC38 tumor mice[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HSV-1 RE strain-infected herpetic stromal keratitis (HSK) mice models[1]
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Dosage:200 μg
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Administration:Intraperitoneally injection, at days 0, 3, 6 and 8
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Result:Showed incidence <5% at all times.
Reduced peak mean severity score.
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Animal Model:Balb/c cardiac grafted C57BL/6 mice[3]
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Dosage:200 μg
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Administration:Intraperitoneally injection, at days 0, 2 and 4
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Result:Displayed only mild leukocyte infiltration, coronary vascular lesions, and fibrosis after 60 days.
Prolonged survival of mice.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo 4-1BBL blockade; ELISA
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Welten SP, et al. The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion. Elife. 2015 Aug 11;4:e07486. [Content Brief]
[2]. Seo SK, et al. Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. J Immunol. 2003 Jul 15;171(2):576-83. [Content Brief]
[3]. Cho HR, et al. Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival. Transpl Int. 2004 Aug;17(7):351-61. [Content Brief]
[4]. Miki H, et al. 4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis. J Immunol. 2020 Apr 1;204(7):1892-1903. [Content Brief]
[5]. Cho E, et al. 4-1BB-4-1BBL cis-interaction contributes to the survival of self-reactive CD8+ T cell. Cell Mol Immunol. 2023 Sep;20(9):1077-1080. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) Related Classifications
HY-P990304 Related Classifications
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