Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)
Based on 1 Customer Validation
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic mouse-derived IgG2a κ antibody, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection.
For research use only. We do not sell to patients.
- Purity : 98.86%
- Molecular Weight:145.96 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
4-1BB/CD137
In Vivo
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) (100 μg, i.p., every other day from day 4 after infection) slightly enhances the numbers of virus-specific CD4+ T cells and greatly augments GzmB expression in Friend retrovirus infected mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CT2A tumor mice models[1]
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Dosage:200 μg
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Administration:Intraperitoneally injection, every 3 days from day 9
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Result:Decreased co-expression of the immune checkpoints TIM-3 and LAG-3.
Decreased CD8+ tumor infiltrating lymphocytes co-expressing PD-1, TIM-3, and LAG-3.
Prolonged survival of mice.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
in vivo activation of 4-1BB
Verified Bioactivity
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Immobilized Mouse CD137 Protein, His Tag can bind Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3). The EC50 for this effect is 41.5 ng/mL.
Chemical Information
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Appearance Liquid
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Molecular Weight 145.96 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Woroniecka KI, et al. 4-1BB Agonism Averts TIL Exhaustion and Licenses PD-1 Blockade in Glioblastoma and Other Intracranial Cancers. Clin Cancer Res. 2020 Mar 15;26(6):1349-1358. [Content Brief]
[2]. Manzke N, et al. CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells. J Virol. 2013 Jun;87(11):6306-13. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) Related Classifications
HY-P990809 Related Classifications
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