2. Apoptosis
  3. TNF Receptor
  4. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) 

Cat. No.: HY-P990809 Purity: 98.86%
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Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic mouse-derived IgG2a κ antibody, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection.

For research use only. We do not sell to patients.

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic mouse-derived IgG2a κ antibody, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection[1][2].

Isotype

Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

4-1BB/CD137
In Vivo

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) (200 μg, i.p., every 3 days from day 9) improves glioblastoma tumor infiltrating lymphocytes function and prolongs survival companied with anti-PD-1 (HY-P99144) in CT2A tumor mice[1].
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) (100 μg, i.p., every other day from day 4 after infection) slightly enhances the numbers of virus-specific CD4+ T cells and greatly augments GzmB expression in Friend retrovirus infected mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT2A tumor mice models[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, every 3 days from day 9
Result: Decreased co-expression of the immune checkpoints TIM-3 and LAG-3.
Decreased CD8+ tumor infiltrating lymphocytes co-expressing PD-1, TIM-3, and LAG-3.
Prolonged survival of mice.
Gene ID

21942  [NCBI]

Accession
Application

in vivo activation of 4-1BB
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.96 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized Mouse CD137 Protein, His Tag can bind Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3). The EC50 for this effect is 41.5 ng/mL.
Purity & Documentation
References
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Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)TNF ReceptorTumor Necrosis Factor ReceptorTNFR4-1BBCD137T cellGlioblastomaRetrovirusCT2AInhibitorinhibitorinhibit

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