2. Apoptosis
  3. TNF Receptor
  4. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) 

Cat. No.: HY-P990809 Purity: 98.86%
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Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic mouse-derived IgG2a κ antibody, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection.

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사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

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Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) Featured Recommendations:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic mouse-derived IgG2a κ antibody, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection[1][2].

Isotype

Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

4-1BB/CD137
In Vivo

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) (200 μg, i.p., every 3 days from day 9) improves glioblastoma tumor infiltrating lymphocytes function and prolongs survival companied with anti-PD-1 (HY-P99144) in CT2A tumor mice[1].
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) (100 μg, i.p., every other day from day 4 after infection) slightly enhances the numbers of virus-specific CD4+ T cells and greatly augments GzmB expression in Friend retrovirus infected mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT2A tumor mice models[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, every 3 days from day 9
Result: Decreased co-expression of the immune checkpoints TIM-3 and LAG-3.
Decreased CD8+ tumor infiltrating lymphocytes co-expressing PD-1, TIM-3, and LAG-3.
Prolonged survival of mice.
Gene ID

21942  [NCBI]

Accession
Application

in vivo activation of 4-1BB
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
분자량

145.96 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)]
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized Mouse CD137 Protein, His Tag can bind Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3). The EC50 for this effect is 41.5 ng/mL.
순도&문서
References
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Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)TNF ReceptorTumor Necrosis Factor ReceptorTNFR4-1BBCD137T cellGlioblastomaRetrovirusCT2AInhibitorinhibitorinhibit

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상품명:
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)
Cat. No.:
HY-P990809
수량:
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