Tnfrsf9 - tumor necrosis factor receptor superfamily, member 9 Gene

Also Known as ILA; Ly63; 4-1BB; Cd137; CDw137; A930040I11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21942

Summary

Enables cytokine binding activity; identical protein binding activity; and signaling receptor activity. Acts upstream of or within negative regulation of interleukin-10 production; negative regulation of interleukin-12 production; and regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Is expressed in renal vasculature. Orthologous to human TNFRSF9 (TNF Receptor Superfamily member 9). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf9 Products (3)

mRNA Protein Name
NM_001077508.1 NP_001070976.1 tumor necrosis factor receptor superfamily member 9 isoform 2 precursor
NM_001077509.1 NP_001070977.1 tumor necrosis factor receptor superfamily member 9 isoform 1 precursor
NM_011612.2 NP_035742.1 tumor necrosis factor receptor superfamily member 9 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9418902 MGI
enables signaling receptor activity IPI
IPI: Inferred from physical interaction
8405064 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of immature T cell proliferation in thymus IDA
IDA: Inferred from direct assay
8405064 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 9

  • 4-1BB ligand receptor

  • CD137 antigen

  • T-cell antigen 4-1BB

  • secreted CD137 antigen

Recombinant Tnfrsf9 Proteins

Cat. No. Product Name Accession Purity
HY-P7447 4-1BB/TNFRSF9 Protein, Mouse (HEK293, Fc, solution) P20334 (V24-L187) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72884 4-1BB/TNFRSF9 Protein, Mouse (HEK293, His) P20334/NP_001070977 (V24-L187) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74335 4-1BB/TNFRSF9 Protein, Mouse (isoform 2, HEK293, Fc) NP_001070976 (V24-L211) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P77574 4-1BB/TNFRSF9 Protein, Mouse (isoform 2, HEK293, His) NP_001070976 (V24-L211) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78794 4-1BB/TNFRSF9 Protein, Mouse (Biotinylated, 188a.a, HEK293, His-Avi) Q8R037 (V24-L211) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P7447A 4-1BB/TNFRSF9 Protein, Mouse (HEK293, C-hFc) P20334 (V24-L187) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P990742 Givastomig Inhibitor 98.556% Phase 2
HY-P990040 Exlinkibart Inhibitor 99.66% Phase 2
HY-P99914 Emfizatamab Activator 95.495% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14817 TNFRSF9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17723 Tnfrsf9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24188 Tnfrsf9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990971 Atenastobart Inhibitor 98.473% Unkown
HY-P991024 Solabafusp alfa Inhibitor 97.17% Unkown
HY-P991151 Opamtistomig Inhibitor 99.69% Unkown
HY-P990698 Umizortamig 96.90% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf9 NCBI NCBI:3604