TNFRSF9 - TNF receptor superfamily member 9 Gene

Also Known as ILA; 4-1BB; CD137; CDw137

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3604

About TNFRSF9

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:7,915,871-7,940,839 (from NCBI)

This gene has 4 transcripts (splice variants), 118 orthologues and 21 paralogues. Biased expression in lymph node (RPKM 2.6), appendix (RPKM 1.1) and 6 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell Apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

TNFRSF9 Products (1)

mRNA	Protein	Name
NM_001561.6	NP_001552.2	tumor necrosis factor receptor superfamily member 9 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF9 Protein Structure

TNFR_c6

0
100
200
255 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 9	4-1BB ligand receptor

TNFRSF9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNFRSF9	Q07011	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7125	4-1BB/TNFRSF9 Protein, Human	Q07011 (E19-S184)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7317	4-1BB/TNFRSF9 Protein, Human (CHO, Fc)	Q07011 (L24-Q186)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70678	4-1BB/TNFRSF9 Protein, Human (HEK293, His)	Q07011 (L24-Q186)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70681	4-1BB/TNFRSF9 Protein, Human (HEK293, Fc)	Q07011 (L24-Q186)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78067	4-1BB/TNFRSF9 Protein, Human (Biotinylated, HEK293, His-Avi)	Q07011 (L24-Q186)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78068	4-1BB/TNFRSF9 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q07011 (L24-Q186)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78386	4-1BB/TNFRSF9 Protein, Human (HEK293, Fc-Avi)	Q07011 (L24-Q186)	≥ 95%, as determined by Bis-Tris PAGE.

TNFRSF9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81761	CD137/4-1BB Antibody (YA1506)	FC, ELISA	Human
HY-P84503	CD137/4-1BB Antibody (YA4200)	WB, FC, ELISA	Human
HY-P84503A	CD137/4-1BB Antibody (YA4200)(PBS only)	WB, FC, ELISA	Human
HY-P84962	CD137/4-1BB Antibody (YA4654)	ELISA	Human

Related Diseases

Diseases	Alias
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Immunodeficiency 16	Combined Immunodeficiency Due To Ox40 Deficiency IMD16 Ox40 Deficiency Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma Combined Immunodeficiency With Impaired Immunity To Hhv-8 Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8 Immunodeficiency, Type 16
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Primary Mediastinal B-Cell Lymphoma	Large Cell Lymphoma Of The Mediastinum Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
B-Lymphoblastic Leukemia/Lymphoma	B Lymphoblastic Leukemia/Lymphoma B-All Precursor B Lymphoblastic Lymphoma/Leukemia C-All Lymphoblastic Lymphoma, Nos Common Precursor B All Lymphoblastic B-Cell Lymphoma Pro-B All B-Precursor Lymphoma Lbl - [Lymphoblastic Lymphoma]
Lymphoproliferative Syndrome 2	Cd27 Deficiency LPFS2 Combined Immunodeficiency Due To Cd27 Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Mixed Oligodendroglioma-Astrocytoma	Who Grade Ii Mixed Glioma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990742	Givastomig	Inhibitor	98.556%	Phase 2
HY-P990040	Exlinkibart	Inhibitor	99.66%	Phase 2
HY-P99914	Emfizatamab	Activator	95.495%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14817	TNFRSF9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17723	Tnfrsf9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24188	Tnfrsf9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990971	Atenastobart	Inhibitor	98.473%	Unkown
HY-P991024	Solabafusp alfa	Inhibitor	97.17%	Unkown
HY-P991151	Opamtistomig	Inhibitor	99.69%	Unkown
HY-P990698	Umizortamig		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNFRSF9	RGD	RGD:1598208
Canis familiaris	TNFRSF9	VGNC	VGNC:47668
Bos taurus	TNFRSF9	VGNC	VGNC:36171
Mus musculus	TNFRSF9	MGD	MGI:1101059
Felis catus	TNFRSF9	VGNC	VGNC:107682
Macaca mulatta	TNFRSF9	VGNC	VGNC:78592
Others	TNFRSF9	NCBI