4 Results for "

95D cells

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "95D cells" in MCE Product Catalog:

Isocryptotanshinone
Isocryptotanshinone
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Cat. No.: HY-N6651
CAS No.: 22550-15-8
Category:  

Quinones Labiatae Samanea saman (Jacq.) Merr. Plants Disease Research Fields Naphthalene Quinones Cancer

Target:  

STAT Phosphatase Apoptosis Autophagy p38 MAPK EGFR JAK Bcl-2 Family Survivin Akt mTOR PARP Caspase Atg8/LC3 CDK

Isocryptotanshinone is a dual STAT3 and PTP1B (IC50 = 56.1 μM) inhibitor. Isocryptotanshinone inhibits STAT3 by binding to the STAT3 SH2 domain to block phosphorylation and nuclear translocation [1][2]. Isocryptotanshinone exerts its anti-proliferative effect via the induction of cell cycle arrest, apoptosis, and pro-death autophagy, through the regulation of STAT3, AKT/mTOR and MAPK signaling pathways. Isocryptotanshinone suppresses the xenograft gastric cancer (GC) tumor growth in BALB/c nude mice. Isocryptotanshinone can be used for cancer research, such as lung cancer, breast cancer and GC .
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Penicinoline
Penicinoline
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Cat. No.: HY-158721
CAS No.: 1214268-60-6
Synonyms: Marinamide
Category:  

Alkaloids Microorganisms Indole Alkaloids

Target:  

Endogenous Metabolite Parasite

Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .
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Ganosinensic acid C
Ganosinensic acid C
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Cat. No.: HY-N8230
CAS No.: 2231756-23-1
Category:  

Microorganisms Ketones, Aldehydes, Acids

Target:  

HIV HIV Protease

Ganosinensic acid C is a triterpenoid compound that can be extracted from Ganoderma lucidum. Ganosinensic acid C has important biological activities such as anti-tumor, anti-prostate cancer, anti-inflammatory, and inhibition of HIV-I protease. Ganosinensic acid C has an IC50 value of 10.5 μM against human highly metastatic lung cancer cell line 95D. Ganosinensic acid C has an IC50 value of Ganosinensic acid C against cervical cancer cell line Hela is 13.2 μM .
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ELMO2-IN-1
ELMO2-IN-1
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Cat. No.: HY-183635
CAS No.: 1216514-48-5
Target:  

Autophagy

Research Areas:  

Cancer

ELMO2-IN-1 is an ELMO2 inhibitor with a human target Kd of 1.0 µM. ELMO2-IN-1 binds to ELMO2, disrupting its function. ELMO2-IN-1 induces autophagy-dependent cell death. ELMO2-IN-1 can be used for the research of non-small cell lung cancer .
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