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Aglaia

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (1) Drug Derivative (1) Eukaryotic Initiation Factor (eIF) (3) Fluorescent Dye (2) FXR (1) HSP (2) NF-κB (2) Parasite (1)
By Research Areas:	Cancer (7) Infection (1) Inflammation/Immunology (2)

Inhibitors & Agonists

Peptides

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Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19356

Rocaglamide Maximum Cited Publications 30 Publications Verification Roc-A	NF-κB HSP Eukaryotic Initiation Factor (eIF)	Inflammation/Immunology Cancer
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia .

HY-19355

Rocagloic acid 1 Publications Verification	Others	Cancer
Rocagloic acid is a racaglamide derivative isolated from the fruits of Aglaia elliptifolia with potent cytotoxicity .

HY-15359

Episilvestrol 1 Publications Verification	Eukaryotic Initiation Factor (eIF) Autophagy	Cancer
Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia perviridis, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity.

HY-P4406

*Abz-AGLA-Nba* 1 Publications Verification	Fluorescent Dye	Others
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .

HY-N11958

5-Hydroxy-3,6,7,4'-tetramethoxyflavone	Others	Others
5-Hydroxy-3,6,7,4'-tetramethoxyflavone is a natural compound isolated from Aglaia edulis .

HY-P4406A

*Abz-AGLA-Nba TFA*	Fluorescent Dye	Others
Abz-AGLA-Nba TFA is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba TFA is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .

HY-19356B

(+)-Rocaglamide	Drug Derivative NF-κB HSP Eukaryotic Initiation Factor (eIF)	Inflammation/Immunology Cancer
(+)-Rocaglamide is the dextrorotatory enantiomer of Rocaglamide (HY-19356). Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of 50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia .

HY-N2975

Cabraleadiol 3-Epiocotillol II	Others	Others
Cabraleadiol (3-Epiocotillol II) is isolated from the MeOH extract of the bark of Aglaia crassinervia .

HY-N8939

Desmethylrocaglamide	Others	Others
Desmethylrocaglamide is a Alkaloids product that can be isolated from the twigs of Aglaia odorata. .

HY-N1822

3-epi-Cabraleahydroxylactone	Others	Others
3-epi-Cabraleahydroxylactone (compound 3) is a triterpenoid that can be found in Aglaia angustifolia Miq .

HY-N8907

3'-Hydroxydehydroaglaiastatin	Others	Others
3'-Hydroxydehydroaglaiastatin is a Alkaloids product that can be isolated from the herbs of Aglaia odorata Lour .

HY-N3212

Naringenin trimethyl ether	Parasite	Infection
Naringenin trimethyl ether is a constituent of twigs and leaves of Aglaia duperreana. Naringenin trimethyl exhibits significant molluscicidal activity, with a LC₅₀ of 3.9 μg/ mL for P. canaliculata .

HY-N3154

Odorinol	Others	Cancer
Odorinol is a natural product isolated from branches and leaves of Aglaia odorata. Odorinol has potential antineoplastic activity and can inhibit both the initiation and promotion stages of skin cancer .

HY-N3155

Odorine Roxburghiline	Others	Cancer
Odorine (Roxburghiline) is a natural product isolated from branches and leaves of Aglaia odorata. Odorine has potential antineoplastic activity and can inhibit both the initiation and promotion stages of skin cancer .

HY-N2827

Aglain C (-)-Aglain C	Others	Others
Aglain C is isolated from A. ponapensis. Aglain C enhances the NF-kB inhibitory activity .

HY-N1841

Rocaglamide D 3'-Hydroxyrocaglamide	Others	Cancer
Rocaglamide D (3'-Hydroxyrocaglamide) (compound 1) is a lignan that can be found in Aglaia odorata. Rocaglamide D shows cytotoxicity with IC₅₀s of 0.32, 0.12, 0.25 µM for HeLa, SGC-7901, A549 cells, respectively .

HY-N8584

(20S,25S)-20,25-Epoxy-25-methoxy-24,24-dimethyl-26,27-dinordammaran-3-one	Others	Others
(20S,25S)-20,25-Epoxy-25-methoxy-24,24-dimethyl-26,27-dinordammaran-3-one is a Triterpenoids product that can be isolated from the twigs of Aglaia perviridis .

HY-N2829

Aglinin A	Others	Others
Aglinin A is a Triterpenoids product that can be isolated from the leaves of Aglaia perviridis .

HY-N9052

Dehydroaglaiastatin	Others	Others
Dehydroaglaiastatin is a Alkaloids product that can be isolated from the herbs of Aglaia odorata Lour .

HY-N3275

Methyl eichlerianate	Others	Others
Methyl eichlerianate is a Triterpenoids product that can be isolated from the barks of Aglaia lanuginose. .

HY-N2654

3-Hydroxy-4',5,7-trimethoxyflavanone	Others	Others
3-Hydroxy-4',5,7-trimethoxyflavanone is a Flavonoids product that can be isolated from the herbs of Aglaia odorata .

HY-N10164

5,6-Desmethylenedioxy-5-methoxyaglalactone	Others	Others
5,6-Desmethylenedioxy-5-methoxyaglalactone is a Phenols product that can be isolated from the leaves and twigs of Aglaia ponapensis. .

HY-N1749

2-Oxokolavenol	FXR	Others
2-Oxokolavenol is a selective agonist targeting the farnesoid X receptor (FXR), with an EC₅₀ of ~3.7 μM. 2-Oxokolavenol exerts its activity against Acetaminophen (HY-66005)-induced hepatocyte damage in an FXR-dependent manner by binding to the FXR ligand-binding pocket, recruiting co-activators, and inducing FXR transcriptional activity. 2-Oxokolavenol can be naturally extracted from Aglaia spectabilis (a plant of the Aglaia genus in the Meliaceae family) and can be used in research related to liver diseases .

Cat. No.	Product Name	Target	Research Area

HY-P4406

*Abz-AGLA-Nba* 1 Publications Verification	Fluorescent Dye	Others
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .

HY-P4406A

*Abz-AGLA-Nba TFA*	Fluorescent Dye	Others
Abz-AGLA-Nba TFA is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba TFA is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .

Rocaglamide Maximum Cited Publications 30 Publications Verification Roc-A	Alkaloids Classification of Application Fields Other Alkaloids Plants Meliaceae Disease Research Fields Aglaia elliptifolia Source Classification Cancer	NF-κB HSP Eukaryotic Initiation Factor (eIF)
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia .

Rocagloic acid 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Plants Meliaceae Disease Research Fields Aglaia elliptifolia Source Classification Cancer	Others
Rocagloic acid is a racaglamide derivative isolated from the fruits of Aglaia elliptifolia with potent cytotoxicity .

Episilvestrol 1 Publications Verification	Natural Products Classification of Application Fields Plants Meliaceae Disease Research Fields Aglaia perviridis Hiern Cancer	Eukaryotic Initiation Factor (eIF) Autophagy
Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia perviridis, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity.

5-Hydroxy-3,6,7,4'-tetramethoxyflavone	Flavonoids Aglaia edulis (Roxburgh) Wallich Flavones Plants Meliaceae Source Classification	Others
5-Hydroxy-3,6,7,4'-tetramethoxyflavone is a natural compound isolated from Aglaia edulis .

Cabraleadiol 3-Epiocotillol II	Triterpenes Terpenoids Plants Aglaia crassinervia Kurz ex Hiern Meliaceae Source Classification	Others
Cabraleadiol (3-Epiocotillol II) is isolated from the MeOH extract of the bark of Aglaia crassinervia .

Desmethylrocaglamide	Alkaloids Other Alkaloids Aglaia odorata Lour. Plants Meliaceae Source Classification	Others
Desmethylrocaglamide is a Alkaloids product that can be isolated from the twigs of Aglaia odorata. .

3-epi-Cabraleahydroxylactone	Triterpenes Terpenoids Plants Meliaceae Aglaia angustifolia (Miq.) Miq. Source Classification	Others
3-epi-Cabraleahydroxylactone (compound 3) is a triterpenoid that can be found in Aglaia angustifolia Miq .

3'-Hydroxydehydroaglaiastatin	Alkaloids Other Alkaloids Plants Meliaceae Source Classification	Others
3'-Hydroxydehydroaglaiastatin is a Alkaloids product that can be isolated from the herbs of Aglaia odorata Lour .

Naringenin trimethyl ether	Infection Flavonoids other families Classification of Application Fields Flavonones Plants Disease Research Fields Source Classification	Parasite
Naringenin trimethyl ether is a constituent of twigs and leaves of Aglaia duperreana. Naringenin trimethyl exhibits significant molluscicidal activity, with a LC₅₀ of 3.9 μg/ mL for P. canaliculata .

Odorinol	Natural Products Aglaia odorata Lour. Plants Meliaceae Source Classification	Others
Odorinol is a natural product isolated from branches and leaves of Aglaia odorata. Odorinol has potential antineoplastic activity and can inhibit both the initiation and promotion stages of skin cancer .

Odorine Roxburghiline	Structural Classification Alkaloids Pyrrole Alkaloids Aglaia odorata Lour. Plants Meliaceae Source Classification	Others
Odorine (Roxburghiline) is a natural product isolated from branches and leaves of Aglaia odorata. Odorine has potential antineoplastic activity and can inhibit both the initiation and promotion stages of skin cancer .

Aglain C (-)-Aglain C	Natural Products Aglaia argentea Blume Plants Meliaceae Source Classification	Others
Aglain C is isolated from A. ponapensis. Aglain C enhances the NF-kB inhibitory activity .

Rocaglamide D 3'-Hydroxyrocaglamide	Lignans Aglaia odorata Lour. Phenylpropanoids Plants Meliaceae Source Classification	Others
Rocaglamide D (3'-Hydroxyrocaglamide) (compound 1) is a lignan that can be found in Aglaia odorata. Rocaglamide D shows cytotoxicity with IC₅₀s of 0.32, 0.12, 0.25 µM for HeLa, SGC-7901, A549 cells, respectively .

(20S,25S)-20,25-Epoxy-25-methoxy-24,24-dimethyl-26,27-dinordammaran-3-one	Triterpenes Terpenoids Plants Meliaceae Aglaia perviridis Hiern Source Classification	Others
(20S,25S)-20,25-Epoxy-25-methoxy-24,24-dimethyl-26,27-dinordammaran-3-one is a Triterpenoids product that can be isolated from the twigs of Aglaia perviridis .

Aglinin A	Triterpenes Terpenoids Plants Meliaceae Aglaia perviridis Hiern Source Classification	Others
Aglinin A is a Triterpenoids product that can be isolated from the leaves of Aglaia perviridis .

Dehydroaglaiastatin	Structural Classification Alkaloids Pyrrole Alkaloids Aglaia odorata Lour. Plants Meliaceae Source Classification	Others
Dehydroaglaiastatin is a Alkaloids product that can be isolated from the herbs of Aglaia odorata Lour .

Methyl eichlerianate	Triterpenes Aglaia grandis Korth. ex Miq. Terpenoids Plants Meliaceae Source Classification	Others
Methyl eichlerianate is a Triterpenoids product that can be isolated from the barks of Aglaia lanuginose. .

3-Hydroxy-4',5,7-trimethoxyflavanone	Flavonoids Plants Meliaceae Source Classification	Others
3-Hydroxy-4',5,7-trimethoxyflavanone is a Flavonoids product that can be isolated from the herbs of Aglaia odorata .

5,6-Desmethylenedioxy-5-methoxyaglalactone	Phenols Aglaia odorata Lour. Plants Meliaceae Source Classification	Others
5,6-Desmethylenedioxy-5-methoxyaglalactone is a Phenols product that can be isolated from the leaves and twigs of Aglaia ponapensis. .

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Aglaia

Inhibitors & Agonists

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