2 Results for "

Antcin K

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Antcin K" in MCE Product Catalog:

Antcin K
Antcin K
0 Images
Cat. No.: HY-N9980
CAS No.: 741268-13-3
Category:  

Microorganisms Steroids

Target:  

PI3K Akt NF-κB p38 MAPK AP-1

Antcin K is a selective inhibitor targeting the PI3K/Akt, NF-κB, MEK1/2-ERK, p38 and AP-1 pathways. Antcin K upregulates IL-10 expression, thereby inhibiting the production of pro-inflammatory factors, blocking monocyte adhesion, reducing tissue damage, and promoting myogenesis. Antcin K has significant anti-inflammatory, anti-damage and tissue protective activities. Antcin K is mainly used in the research of inflammation-related diseases such as periodontitis, rheumatoid arthritis, and skeletal muscle injury .
loading...
    loading...
View All Sizes
Antcin A
Antcin A
0 Images
Cat. No.: HY-N9921
CAS No.: 163597-24-8
Category:  

Microorganisms Steroids

Target:  

Pyroptosis NOD-like Receptor (NLR) MDM-2/p53 Glucocorticoid Receptor MicroRNA Na+/K+ ATPase SARS-CoV

Antcin A is an orally active modulator of p53 and glucocorticoid receptor (GR), with an IC50 of 8.55 μM against human GR. Through transcriptional activation of p53, Antcin A induces miR-200c and inhibits ZEB1, regulates epithelial-mesenchymal transition markers, and suppresses cancer cell migration/invasion. Antcin A activates GR, inhibits Na +/K +-ATPase and NLRP3 inflammasome assembly, pyroptosis (pyroptosis) and pro-inflammatory cytokine release, reduces hepatic lipid deposition, improves liver function, and reverses metabolic changes induced by the SARS-CoV-2 spike protein. Antcin A can be used in research related to breast cancer, head and neck cancer, non-alcoholic fatty liver disease, and coronavirus disease 2019 (COVID-19) .
loading...
    loading...
View All Sizes
Assay Types