741268-13-3
Chemical Structure
Antcin K
- CAS No.: 741268-13-3
- Formula:C29H44O6
- Molecular Weight:488.66
IUPAC Name: (6R)-2-methyl-3-methylene-6-((3R,4R,5R,7S,10S,13R,14R,17R)-3,4,7-trihydroxy-4,10,13-trimethyl-11-oxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)heptanoic acid
InChIKey: RWTLLOHEXIZDCG-DOZCWRSDSA-N
SMILES: C[C@@]12C3=C([C@H](C[C@@]1([H])[C@@](O)([C@@H](CC2)O)C)O)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC(C(C)C(O)=O)=C)C
Biological Activity: Antcin K is a selective inhibitor targeting the PI3K/Akt, NF-κB, MEK1/2-ERK, p38 and AP-1 pathways. Antcin K upregulates IL-10 expression, thereby inhibiting the production of pro-inflammatory factors, blocking monocyte adhesion, reducing tissue damage, and promoting myogenesis. Antcin K has significant anti-inflammatory, anti-damage and tissue protective activities. Antcin K is mainly used in the research of inflammation-related diseases such as periodontitis, rheumatoid arthritis, and skeletal muscle injury[1][2][3].
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Antcin K | Antcin K is a selective inhibitor targeting the PI3K/Akt, NF-κB, MEK1/2-ERK, p38 and AP-1 pathways. Antcin K upregulates IL-10 expression, thereby inhibiting the production of pro-inflammatory factors, blocking monocyte adhesion, reducing tissue damage, and promoting myogenesis. Antcin K has significant anti-inflammatory, anti-damage and tissue protective activities. Antcin K is mainly used in the research of inflammation-related diseases such as periodontitis, rheumatoid arthritis, and skeletal muscle injury. | |||||||||||||||||||||
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- [1]. Wu YH, et al. Antcin K suppresses proinflammatory cytokines expression via the PI3K, Akt and NF-κB pathways in human gingival fibroblasts: implications for periodontitis treatment. Cell Death Discov. 2025 Nov 22. [Content Brief]
- [2]. Achudhan D, et al. Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts. Food Nutr Res. 2022 Jun 2;66. [Content Brief]
- [3]. Chang TK, et al. Antcin K ameliorates cardiotoxin-induced skeletal muscle injury and inflammation via IL-10 regulation. Int J Biol Sci. 2025 Mar 19;21(6):2493-2507. [Content Brief]
Keywords
