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Results for "

BIRC5

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

6

Recombinant Proteins

7

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124447
    BTYNB

    		IGF-1R c-Myc Apoptosis TGF-beta/Smad Cancer
    BTYNB is a structure-specific nucleic acid binder and IGF2BP1 inhibitor (with an IC50 of 5 μM against hBTYNB). BTYNB disrupts the IGF2BP1-RNA interaction and blocks its binding to oncogenic mRNAs such as c-Myc, MDM2, PD-L1. BTYNB completely blocks the INHBA-Smad2/3 pathway, disrupts the MYCN/IGF2BP1 loop, and thereby induces apoptosis and cell cycle arrest, effectively inhibiting the proliferation and survival of cancer cells. In addition, BTYNB acts as an immune activator and tumor microenvironment modulator, enhances T cell-mediated tumor killing, and produces significant synergistic effects with inhibitors of PD-1, BRD and BIRC5. BTYNB can be used in relevant research on various malignant tumors including ovarian cancer, neuroblastoma, leukemia and melanoma [5].
    BTYNB
  • HY-175352
    Nurr1 agonist 14

    		Nuclear Hormone Receptor 4A/NR4A SOD IAP Survivin Calcium Channel Neurological Disease
    Nurr1 agonist 14 (Compound 32) is a Nurr1 agonist with an EC50 of 0.09  μM for Nurr1. Nurr1 agonist 14 has significant neuroprotective activity with no influence of residual DHODH inhibition. Nurr1 agonist 14 upregulates neuroprotective genes including SOD2, SESN3, BIRC5, XIAP, FLRT2 and CRMP4 in dopaminergic neurons. Nurr1 agonist 14 can be used for neurodegenerative diseases such as Alzheimer′s disease (AD), Parkinson′s disease (PD) and multiple sclerosis (MS) research .
    Nurr1 agonist 14
  • HY-173025
    Nurr1 agonist 12

    		Nuclear Hormone Receptor 4A/NR4A Neurological Disease
    Nurr1 agonist 12 (Compound 37) is the agonist for nuclear receptor-associated protein 1 (Nurr1) that activates the transcriptional activity of Nurr1 with an EC50 of 0.06 μM. Nurr1 agonist 12 activates the human response elements NBRE, NurRE, and DR5 with EC50 of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Nurr1 agonist 12 induces the expression of Nurr1-regulated neurotrophic genes, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin). Nurr1 agonist 12 exhibits neuroprotective efficacy against Paraquat-induced neurotoxicity .
    Nurr1 agonist 12
  • HY-RS01513
    BIRC5 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    BIRC5 Human Pre-designed siRNA Set A contains three designed siRNAs for BIRC5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    BIRC5 Human Pre-designed siRNA Set A
    BIRC5 Human Pre-designed siRNA Set A
  • HY-RS24371
    Birc5 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Birc5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Birc5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Birc5 Rat Pre-designed siRNA Set A
    Birc5 Rat Pre-designed siRNA Set A
  • HY-RS17902
    Birc5 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Birc5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Birc5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Birc5 Mouse Pre-designed siRNA Set A
    Birc5 Mouse Pre-designed siRNA Set A

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