Survivin Antibody (YA6790)
(Synonyms: API4 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; Apoptosis inhibitor4 antibody; Baculoviral IAP repeat containing 5 antibody; Baculoviral IAP repeat containing protein 5 antibody; Baculoviral IAP repeat-containing protein 5 antibody; BIRC 5 antibody; BIRC5 antibody; BIRC5_HUMAN antibody; API4 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; Apoptosis inhibitor4 antibody; Baculoviral IAP repeat containing 5 antibody; Baculoviral IAP repeat containing protein 5 antibody; Baculoviral IAP repeat-containing protein 5 antibody; BIRC 5 antibody; BIRC5 antibody; BIRC5_HUMAN antibody; EPR 1 antibody; IAP4 antibody; Survivin variant 3 alpha antibody; SVV antibody; TIAP antibody; )Survivin Antibody (YA6790) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Survivin.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P, IP
-
Reactivity :
Mouse, Rat
-
Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:50-1:200 |
Product Details
Survivin Antibody (YA6790) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Survivin.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityMouse, Rat
-
Calculated Molecular Weight Predicted band size: 16 kDa
Full length recombinant protein within mouse Survivin.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of survivin induction pathways leading to increase in apoptosis and decrease in tumour growth. Survivin expression is highly regulated by the cell cycle and is only expressed in the G2-M phase. Survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. Survivin is highly expressed in most cancers and associated with chemotherapy resistance, increased tumor recurrence, and shorter patient survival, making antisurvivin therapy an attractive cancer treatment strategy.
-
Subcellular Localization
Cytoplasm,Nucleus,Chromosome,Chromosome, centromere,Cytoplasm, cytoskeleton, spindle,Chromosome, centromere, kinetochore,Midbody
-
Isoforms & Post-Translational Modification
O70201 has three isomers: O70201-1: 16298 Da (predicted); O70201-2: 14154 Da (predicted); O70201-3: 4670 Da (predicted).
Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation丨Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export丨In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes -
Subunit
Monomer or homodimer
-
SwissProt ID
-
Synonyms
API4 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; Apoptosis inhibitor4 antibody; Baculoviral IAP repeat containing 5 antibody; Baculoviral IAP repeat containing protein 5 antibody; Baculoviral IAP repeat-containing protein 5 antibody; BIRC 5 antibody; BIRC5 antibody; BIRC5_HUMAN antibody; API4 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; Apoptosis inhibitor4 antibody; Baculoviral IAP repeat containing 5 antibody; Baculoviral IAP repeat containing protein 5 antibody; Baculoviral IAP repeat-containing protein 5 antibody; BIRC 5 antibody; BIRC5 antibody; BIRC5_HUMAN antibody; EPR 1 antibody; IAP4 antibody; Survivin variant 3 alpha antibody; SVV antibody; TIAP antibody;
Documentation
Powered by Bioz
