14 Results for "

Bid BH3

" in MedChemExpress (MCE) Product Catalog:
Products (14)

14 Results for "Bid BH3" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-103661
CAS No.: 791835-21-7
Purity:  98.47%
Research Areas:  

Neurological Disease

BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .
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Cat. No.: HY-P5325A
Target:  

Bcl-2 Family

Research Areas:  

Others

Bid BH3 (80-99) acetate is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)
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Cat. No.: HY-P5325
CAS No.: 505070-05-3
Target:  

Bcl-2 Family

Research Areas:  

Others

Bid BH3 (80-99) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)
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Cat. No.: HY-P10614
CAS No.: 300349-78-4
Target:  

Apoptosis Bcl-2 Family

Research Areas:  

Cancer

Bid BH3 peptide is a pro-apoptotic peptide derived from the Bid protein. Through its α-helical conformation, Bid BH3 peptide inserts into the hydrophobic grooves of anti-apoptotic Bcl-2 family proteins (Bcl-xl, Bcl-2, Bcl-w and Bax), competitively displaces and releases the pro-apoptotic proteins Bax/Bak, thereby initiating mitochondrial outer membrane permeabilization (MOMP) and the caspase cascade for apoptosis. Bid BH3 peptide can be used in cancer-related research .
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Cat. No.: HY-P5327
Target:  

Bcl-2 Family

Research Areas:  

Others

r8 Bid BH3 is a biological active peptide. (The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.)
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Cat. No.: HY-P5325F
Target:  

Bcl-2 Family

Research Areas:  

Others

Bid BH3 (80-99), FAM labeled is a biological active peptide. (This is a 5-FAM-labeled Bid BH3 HY-P5325 peptide.)
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Cat. No.: HY-P11374
Target:  

Bcl-2 Family Apoptosis

Research Areas:  

Cancer

Bid BH3-Gly-r8 is Bid BH3 linked to eight arginine residues. Bid BH3-Gly-r8 shows no difference in apoptotic effects compared to its unmodified peptide homologue. Bid BH3 has high affinity for Bax and Bcl-2. Bid BH3-Gly-r8 can be used in the research of tumors .
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Cat. No.: HY-P10614A
Target:  

Apoptosis Bcl-2 Family

Research Areas:  

Cancer

Bid BH3 peptide acetate is a pro-apoptotic peptide derived from the Bid protein. Through its α-helical conformation, Bid BH3 peptide inserts into the hydrophobic grooves of anti-apoptotic Bcl-2 family proteins (Bcl-xl, Bcl-2, Bcl-w and Bax), competitively displaces and releases the pro-apoptotic proteins Bax/Bak, thereby initiating mitochondrial outer membrane permeabilization (MOMP) and the caspase cascade for apoptosis. Bid BH3 peptide acetate can be used in cancer-related research .
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Cat. No.: HY-123244
CAS No.: 810659-53-1
Target:  

Bcl-2 Family Apoptosis

Research Areas:  

Cancer

YC137 is a potent Bcl-2 antagonist with Kis of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research .
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Cat. No.: HY-P7662
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Bid; Human Bid Coding Sequence; BH3 Interacting Domain Death Agonist; Apoptic Death Agonist; BH3-Interacting Domain Death Agonist; Desmocollin Type 4; P22 Bid; Bid Isoform Si6; BH3 Interacting Domain Death Agonist Si6 Isoform; FP497
Species:  
Source:  
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Cat. No.: HY-P701328
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Bid; Human Bid Coding Sequence; BH3 Interacting Domain Death Agonist; Apoptic Death Agonist; BH3-Interacting Domain Death Agonist; Desmocollin Type 4; P22 Bid; Bid Isoform Si6; BH3 Interacting Domain Death Agonist Si6 Isoform; FP497
Species:  
Source:  
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Cat. No.: HY-P72852
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Bid; Human Bid Coding Sequence; BH3 Interacting Domain Death Agonist; Apoptic Death Agonist; BH3-Interacting Domain Death Agonist; Desmocollin Type 4; P22 Bid; Bid Isoform Si6; BH3 Interacting Domain Death Agonist Si6 Isoform; FP497
Species:  
Source:  
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Cat. No.: HY-103661R
CAS No.: 791835-21-7
BI-6C9 (Standard) is the analytical standard of BI-6C9 (HY-103661). This product is intended for research and analytical applications. BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .
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Cat. No.: HY-P85054
Synonyms: Bid; BH3-interacting domain death agonist; p22 Bid; Bid

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, FC, ELISA

Reactivity:  

Human

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