BID Antibody (YA4746)
(Synonyms: BID; BH3-interacting domain death agonist; p22 BID; BID)BID Antibody (YA4746) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to BID.
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Host:
Mouse
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Application:
WB, IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
BID Antibody (YA4746) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to BID.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 22 kDa;
Purified recombinant fragment of human BID expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BID induces caspases and apoptosis. Counters the protective effect of BCL2; Induces caspase activation and apoptosis. Allows the release of cytochrome c; Induces ICE-like proteases and apoptosis; Induces ICE-like proteases and apoptosis; Does not induce apoptosis; Induces ICE-like proteases and apoptosis[1][2][3].
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Subcellular Localization
Cytoplasm; Mitochondrion membrane; Mitochondrion outer membrane; Mitochondrion membrane; Mitochondrion membrane; Cytoplasm; Cytoplasm; Mitochondrion membrane
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Expression
Tissue_specificity:It is expressed in the spleen, pancreas, and placenta (protein level) ; it is expressed in the lungs, pancreas, and spleen (protein level) ; it is expressed in the lungs and pancreas (protein level) . -
Isoforms & Post-Translational Modification
P55957 has 4 isomers: P55957-1: 21995 Da (predicted); P55957-2: 26836 Da (predicted); P55957-3: 14620 Da (predicted); P55957-4: 11263 Da (predicted).
TNF-alpha induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products (By similarity). Cleaved by CASP6 into a major p15 and minor p13 products, leading to release of cytochrome c and subsequent nonalcoholic steatohepatitis (PubMed:32029622);Ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation -
Subunit
Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2 (By similarity). Interacts with PLEKHN1 (PubMed:29531808)
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SwissProt ID
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Synonyms
BID; BH3-interacting domain death agonist; p22 BID; BID
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