BID - BH3 interacting domain death agonist Gene

Also Known as FP497

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 637

About BID

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:17,734,138-17,774,665 (from NCBI)

This gene has 11 transcripts (splice variants) and 90 orthologues. Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 9.4) and 24 other tissues.

Summary

This gene encodes a death agonist that heterodimerizes with either agonist Bax or antagonist BCL2, and thus regulate Apoptosis. The encoded protein is a member of the Bcl-2 Family of cell death regulators. It is a mediator of mitochondrial damage induced by Caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020]

BID Products (7)

mRNA	Protein	Name
NM_001196.4	NP_001187.1	BH3-interacting domain death agonist isoform 2
NM_001244567.1	NP_001231496.1	BH3-interacting domain death agonist isoform 2
NM_001244569.1	NP_001231498.1	BH3-interacting domain death agonist isoform 3
NM_001244570.1	NP_001231499.1	BH3-interacting domain death agonist isoform 3
NM_001244572.1	NP_001231501.1	BH3-interacting domain death agonist isoform 3
NM_197966.3	NP_932070.1	BH3-interacting domain death agonist isoform 1
NM_197967.2	NP_932071.1	BH3-interacting domain death agonist isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9463381	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in establishment of protein localization to membrane	IDA IDA: Inferred from direct assay	21041309	GOA
involved in hepatocyte apoptotic process	IDA IDA: Inferred from direct assay	32029622	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21459798	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21262771	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	19074440	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	32029622	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IGI IGI: Inferred from genetic interaction	21041309	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	17052454	GOA
involved in supramolecular fiber organization	IDA IDA: Inferred from direct assay	33106313	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	29531808	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BID Protein Structure

BID

0
100
195 a.a.

Protein Preferred Names	Protein Names
BH3-interacting domain death agonist	Human BID coding sequence

BID Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BID	P55957	BCL2L1	Homo sapiens	Q07817-1	SPR	17289999
Intra	BID	P55957	BCL2L1	Homo sapiens	Q07817-1	FPS	19074440
Intra	BID	P55957	BCL2L1	Homo sapiens	Q07817-1	SPR	15694340
Intra	BID	P55957	BCL2L1	Homo sapiens	Q07817-1	Anti Tag CoIP	17289999
Intra	BID	P55957	BAX	Homo sapiens	Q07812	Anti Tag CoIP	17289999
Intra	BID	P55957	BAX	Homo sapiens	Q07812	X-Ray Diffraction	23374347
Intra	BID	P55957	BAX	Homo sapiens	Q07812	SPR	17289999
Intra	BID	P55957	BAK1	Homo sapiens	Q16611	NMR	23604079
Intra	BID	P55957	BAK1	Homo sapiens	Q16611	Anti Bait CoIP	23782464
Intra	BID	P55957	BAK1	Homo sapiens	Q16611	Solution Sedimentation	23604079
Intra	BID	P55957	CAV1	Homo sapiens	Q03135	Anti Bait CoIP	21382479
Intra	BID	P55957	CAV1	Homo sapiens	Q03135	Confocal	21382479
Intra	BID	P55957	BCL2L2	Homo sapiens	Q92843	SPR	17289999
Intra	BID	P55957	BCL2L2	Homo sapiens	Q92843	Anti Tag CoIP	17289999
Intra	BID	P55957	BCL2L2	Homo sapiens	Q92843	SPR	15694340
Cross	BID	P55957	Bcl2a1	Mus musculus	Q07440	SPR	17289999
Cross	BID	P55957	OPG035	vaccinia virus	P17361	Anti Bait CoIP	17485524
Cross	BID	P55957	OPG035	vaccinia virus	P17361	FPS	17123957
Intra	BID	P55957	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	BID	P55957	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	BID	P55957	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	BID	P55957	BCL2	Homo sapiens	P10415	CoIP	12624108
Intra	BID	P55957	BCL2	Homo sapiens	P10415	Anti Bait CoIP	9463381
Intra	BID	P55957	BCL2	Homo sapiens	P10415	Anti Tag CoIP	17289999
Intra	BID	P55957	BCL2	Homo sapiens	P10415	FPS	16697956
Intra	BID	P55957	BCL2	Homo sapiens	P10415	SPR	17289999
Intra	BID	P55957	BCL2L1	Homo sapiens	Q07817	PLA	25241761

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BID Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7662	BID Protein, Human	P55957 (M1-D195)	≥ 95%, as determined by reducing SDS-PAGE.

BID Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80031	BID Antibody (YA583)	WB, IHC-P, IHC-F, IF-Tissue, FC, ICC/IF, IP	Human
HY-P84410	BID Antibody (YA4107)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84410A	BID Antibody (YA4107)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P85054	BID Antibody (YA4746)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Clubfoot	Congenital Talipes Equinovarus Congenital Clubfoot Congenital Equinovarus Equinovarus Deformity Of Foot Club Foot

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0493	Niflumic acid	Inhibitor	99.61%	Unkown
HY-B0493R	Niflumic acid (Standard)	Inhibitor	99.93%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-165550	Sphingosine		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10510	BI-D1870		99.43%	Unkown
HY-103661	BI-6C9	Inhibitor	98.47%	Unkown
HY-N0559	Kirenol		99.82%	Unkown
HY-108610A	Edelfosine		99.0%	Unkown
HY-N6005	Methyl caffeate		99.89%	Unkown
HY-125305	Z-AEVD-FMK	Inhibitor	95.0%	Unkown
HY-18601	(±)-BI-D	Inhibitor	98.06%	Unkown
HY-167881	MLS-0053105	Inhibitor	98.89%	Unkown
HY-121683	(E)-2-Hexadecenal		99.9%	Unkown
HY-P5325A	Bid BH3 (80-99) acetate		98.13%	Unkown
HY-RS01502	BID Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-123244	YC137		/	Unkown
HY-162642	Bfl-1-IN-3	Inhibitor	/	Unkown
HY-N0559R	Kirenol (Standard)		/	Unkown
HY-N17676	3-Tridecylphenol		/	Unkown
HY-N7917	Tenacigenoside A		/	Unkown
HY-N8617	Trijuganone C		/	Unkown
HY-P10614	Bid BH3 peptide	Inducer	/	Unkown
HY-P10614A	Bid BH3 peptide acetate	Inducer	/	Unkown
HY-P11374	Bid BH3-Gly-r8	Ligand	/	Unkown
HY-P5325	Bid BH3 (80-99)		/	Unkown
HY-P5325F	Bid BH3 (80-99), FAM labeled		/	Unkown
HY-P5327	r8 Bid BH3		/	Unkown
HY-183402	FLLL12		/	Unkown
HY-RS16655	Bid Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23090	Bid Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BID	VGNC	VGNC:26496
Rattus norvegicus	BID	RGD	RGD:620160
Felis catus	BID	VGNC	VGNC:60115
Macaca mulatta	BID	VGNC	VGNC:70250
Canis familiaris	BID	VGNC	VGNC:38456
Mus musculus	BID	MGD	MGI:108093
Others	BID	NCBI