BID Antibody (YA583)
BID Antibody (YA583) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BID.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, IF-Tissue, FC, ICC/IF, IP
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Reactivity :
Human
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Formulation:
Supplied in10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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FC
FC: Flow Cytometry
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:100-500 | 1:100-500 | 1:50-100 | 1:50-200 | 1:20-50 |
Product Details
BID Antibody (YA583) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BID.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 22kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 22kDa
A synthesized peptide derived from human BID. The exact sequence is proprietary to MCE.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity); Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622); Induces ICE-like proteases and apoptosis; Induces ICE-like proteases and apoptosis; Does not induce apoptosis; Induces ICE-like proteases and apoptosis
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Subcellular Localization
Cytoplasm; Mitochondrion membrane; Mitochondrion outer membrane; Mitochondrion membrane; Mitochondrion membrane; Cytoplasm; Cytoplasm; Mitochondrion membrane
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Expression
Tissue_specificity:It is expressed in the spleen, pancreas, and placenta (protein level) ; it is expressed in the lungs, pancreas, and spleen (protein level) ; it is expressed in the lungs and pancreas (protein level) . -
Isoforms & Post-Translational Modification
P55957 has 4 isomers: P55957-1: 21995 Da (predicted); P55957-2: 26836 Da (predicted); P55957-3: 14620 Da (predicted); P55957-4: 11263 Da (predicted).
TNF-alpha induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products (By similarity). Cleaved by CASP6 into a major p15 and minor p13 products, leading to release of cytochrome c and subsequent nonalcoholic steatohepatitis (PubMed:32029622);Ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation -
Subunit
Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2 (By similarity). Interacts with PLEKHN1 (PubMed:29531808)
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SwissProt ID
Documentation
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