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Results for "

Bitter taste receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Taste Receptor (8) Bacterial (4) Environmental Pollutants (2) Fungal (1) Insecticide (2) Isotope-Labeled Compounds (1) Opioid Receptor (1) Reference Standards (3)
By Research Areas:	Endocrinology (1) Infection (4) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Taste Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100047

Nα,Nα-Bis(carboxymethyl)-L-lysine	Taste Receptor	Others
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC₅₀ of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .

HY-B1146

Denatonium benzoate 1 Publications Verification THS-839	Environmental Pollutants Insecticide	Inflammation/Immunology Endocrinology
Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility .

HY-111664

(R)-(+)-Citronellal (+)-Citronellal	Bacterial Fungal Insecticide Taste Receptor Opioid Receptor	Infection Neurological Disease Inflammation/Immunology
(R)-(+)-Citronellal ((+)-Citronellal) is a monoterpenoid compound and is one of the main components of essential oils from plants such as lemon grass. (R)-(+)-Citronellal has antibacterial, antifungal, and insecticidal activities. (R)-(+)-Citronellal alleviates the bitterness of caffeine by antagonizing the bitter taste receptors Tas2r43 (IC₅₀ = 84 μM) and Tas2R46. (R)-(+)-Citronellal generates analgesic activity by activating the opioid receptor (broad-spectrum opioid receptor) pathway, and its effect is particularly significant for inflammatory pain .

HY-P4648

H-Trp-Trp-Trp-OH Trp-Trp-Trp	Bacterial	Infection
H-Trp-Trp-Trp-OH (Trp-Trp-Trp) is a tripeptide consisting of tryptophan. H-Trp-Trp-Trp-OH has antibacterial activity. H-Trp-Trp-Trp-OH is a human bitter taste receptor hTAS2R14 agonist .

HY-153265

TAS2R14 agonist-2	Taste Receptor	Inflammation/Immunology
TAS2R14 agonist-2 (compound 28.1) is a potent and selective TAS2R14 agonist with an EC₅₀ value of 72 nM. TAS2R14 agonist-2 reveals marked selectivity over a panel of 24 non-bitter taste human G protein-coupled receptors. TAS2R14 agonist-2 can be used for the studies of asthma or chronic obstructive pulmonary disease .

HY-N0742

Absinthin	Others	Others
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca ²⁺-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

HY-B1390A

Saccharin sodium	Environmental Pollutants Bacterial	Infection
Saccharin sodium is an orally active, non-caloric artificial sweetener (NAS). Saccharin sodium has bacteriostatic and microbiome-modulating properties. Saccharin binds to and signals via specific taste receptors, not only in the oral cavity but also alongside the gastrointestinal tract. Saccharin has been reported to bind the human and rodent heteromeric guanine nucleotide-binding protein (G protein) coupled sweet taste receptors T1R2/T2R3 as well as the human bitter taste receptor T2R43 and T2R44. Saccharin can inhibit bacterial growth in vitro .

HY-139898

S7958	Taste Receptor	Others
S7958 is a selective and orally active antagonist of the TAS2R8 bitter taste receptor, with its IC₅₀ being 0.06 μM. S7958 only has a weak inhibitory effect on TASR8 and TAS2R39, and has no significant impact on other receptors. S7958 significantly inhibits the perception of bitterness caused by substances such as coffee and drug active ingredients (API) by selectively antagonizing the human bitter taste receptor TAS2R8. S7958 can be used in the medical field to improve the research on the bitterness of oral preparations .

HY-124956

GIV3727	Taste Receptor	Others
GIV3727 is a bitter taste receptor hTAS2R antagonist, which can inhibit the activation of hTAS2R31 by saccharin and acesulfame potassium, and can effectively reduce the bitter quality of food, beverage and medicine .

HY-153264

TAS2R14 agonist-1	Taste Receptor	Others
TAS2R14 agonist is a potent TAS2R14 partial agonist with an EC₅₀ of 116.6 ±23.6 nM .

HY-W724355

Denatonium benzoate-d5 THS-839-d₅	Isotope-Labeled Compounds Taste Receptor	Metabolic Disease Inflammation/Immunology
Denatonium benzoate-d₅ (THS-839-d₅) is the deuterium labeled Denatonium benzoate (HY-B1146). Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility .

HY-B1390AR

Saccharin sodium (Standard)	Bacterial Reference Standards	Infection
Saccharin (sodium) (Standard) is the analytical standard of Saccharin (sodium). This product is intended for research and analytical applications. Saccharin sodium is an orally active, non-caloric artificial sweetener (NAS). Saccharin sodium has bacteriostatic and microbiome-modulating properties. Saccharin binds to and signals via specific taste receptors, not only in the oral cavity but also alongside the gastrointestinal tract. Saccharin has been reported to bind the human and rodent heteromeric guanine nucleotide-binding protein (G protein) coupled sweet taste receptors T1R2/T2R3 as well as the human bitter taste receptor T2R43 and T2R44. Saccharin can inhibit bacterial growth in vitro .

HY-100047R

Nα,Nα-Bis(carboxymethyl)-L-lysine (Standard)	Taste Receptor Reference Standards	Others
Nα,Nα-Bis(carboxymethyl)-L-lysine (Standard) is the analytical standard of Nα,Nα-Bis(carboxymethyl)-L-lysine (HY-100047). This product is intended for research and analytical applications. Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .

HY-N0742R

Absinthin (Standard)	Reference Standards Others	Others
Absinthin (Standard) is the analytical standard of Absinthin. This product is intended for research and analytical applications. Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

Cat. No.	Product Name	Target	Research Area

HY-100047

Nα,Nα-Bis(carboxymethyl)-L-lysine	Taste Receptor	Others
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC₅₀ of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .

HY-P4648

H-Trp-Trp-Trp-OH Trp-Trp-Trp	Bacterial	Infection
H-Trp-Trp-Trp-OH (Trp-Trp-Trp) is a tripeptide consisting of tryptophan. H-Trp-Trp-Trp-OH has antibacterial activity. H-Trp-Trp-Trp-OH is a human bitter taste receptor hTAS2R14 agonist .

HY-100047R

Nα,Nα-Bis(carboxymethyl)-L-lysine (Standard)	Taste Receptor Reference Standards	Others
Nα,Nα-Bis(carboxymethyl)-L-lysine (Standard) is the analytical standard of Nα,Nα-Bis(carboxymethyl)-L-lysine (HY-100047). This product is intended for research and analytical applications. Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-111664

(R)-(+)-Citronellal (+)-Citronellal	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Citrus limon (L.) Burm. F. Rutaceae Metabolic Disease Plants Endogenous metabolite Disease Research Fields Citrus reticulata Blanco Source Classification	Bacterial Fungal Insecticide Taste Receptor Opioid Receptor
(R)-(+)-Citronellal ((+)-Citronellal) is a monoterpenoid compound and is one of the main components of essential oils from plants such as lemon grass. (R)-(+)-Citronellal has antibacterial, antifungal, and insecticidal activities. (R)-(+)-Citronellal alleviates the bitterness of caffeine by antagonizing the bitter taste receptors Tas2r43 (IC₅₀ = 84 μM) and Tas2R46. (R)-(+)-Citronellal generates analgesic activity by activating the opioid receptor (broad-spectrum opioid receptor) pathway, and its effect is particularly significant for inflammatory pain .

HY-N0742

Absinthin	Triterpenes Classification of Application Fields Terpenoids Other Diseases Plants Acacia confusa Merr. Compositae Disease Research Fields Source Classification	Others
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca ²⁺-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

HY-N0742R

Absinthin (Standard)	Triterpenes Structural Classification Terpenoids Plants Acacia confusa Merr. Compositae Source Classification	Reference Standards Others
Absinthin (Standard) is the analytical standard of Absinthin. This product is intended for research and analytical applications. Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

Cat. No.	Product Name	Chemical Structure

HY-W724355

Denatonium benzoate-d5
Denatonium benzoate-d₅ (THS-839-d₅) is the deuterium labeled Denatonium benzoate (HY-B1146). Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility .

Denatonium benzoate-d5

Denatonium benzoate-d₅ (THS-839-d₅) is the deuterium labeled Denatonium benzoate (HY-B1146). Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility .

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Bitter taste receptor

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products