Saccharin sodium
Based on 1 Customer Validation
Saccharin sodium is an orally active, non-caloric artificial sweetener (NAS). Saccharin sodium has bacteriostatic and microbiome-modulating properties. Saccharin binds to and signals via specific taste receptors, not only in the oral cavity but also alongside the gastrointestinal tract. Saccharin has been reported to bind the human and rodent heteromeric guanine nucleotide-binding protein (G protein) coupled sweet taste receptors T1R2/T2R3 as well as the human bitter taste receptor T2R43 and T2R44. Saccharin can inhibit bacterial growth in vitro.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 128-44-9
- Formula: C7H4NNaO3S
- Molecular Weight:205.17
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Saccharin (5 mM, 0-14 h) exhibits bacteriostatic effects on Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Saccharin (supplemented in water, 7 d) improves intestinal inflammation in acute experimental colitis C57BL/6J wt mice[1].
Saccharin (0.1 mg/mL, supplemented in water, 5 w) has a protective influence on chronic DSS-colitis in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 128-44-9
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Appearance Solid
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Molecular Weight 205.17
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Formula C7H4NNaO3S
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Color White to off-white
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SMILES
O=C(C1=CC=CC=C12)N([Na])S2(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 175 mg/mL (852.95 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (558 KB)
- English - EN (558 KB)
- Français - FR (558 KB)
- Deutsch - DE (558 KB)
- Norwegian - NO (558 KB)
- Español - ES (558 KB)
- Swedish - SV (558 KB)
- Italian - IT (558 KB)
- Korean - KR (558 KB)
- Portuguese - PT (558 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.8740 mL | 24.3700 mL | 48.7401 mL | 121.8502 mL |
| 5 mM | 0.9748 mL | 4.8740 mL | 9.7480 mL | 24.3700 mL | |
| 10 mM | 0.4874 mL | 2.4370 mL | 4.8740 mL | 12.1850 mL | |
| 15 mM | 0.3249 mL | 1.6247 mL | 3.2493 mL | 8.1233 mL | |
| 20 mM | 0.2437 mL | 1.2185 mL | 2.4370 mL | 6.0925 mL | |
| 25 mM | 0.1950 mL | 0.9748 mL | 1.9496 mL | 4.8740 mL | |
| 30 mM | 0.1625 mL | 0.8123 mL | 1.6247 mL | 4.0617 mL | |
| 40 mM | 0.1219 mL | 0.6093 mL | 1.2185 mL | 3.0463 mL | |
| 50 mM | 0.0975 mL | 0.4874 mL | 0.9748 mL | 2.4370 mL | |
| 60 mM | 0.0812 mL | 0.4062 mL | 0.8123 mL | 2.0308 mL | |
| 80 mM | 0.0609 mL | 0.3046 mL | 0.6093 mL | 1.5231 mL | |
| 100 mM | 0.0487 mL | 0.2437 mL | 0.4874 mL | 1.2185 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Saccharin sodium Related Classifications
HY-B1390A Related Classifications
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