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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
CERT
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "CERT" in MCE Product Catalog:
1
1 Cited Publications
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Research Areas:
HPA-12 is a blood-brain barrier-permeable small-molecule inhibitor of ceramide transfer protein (CERT) with four stereoisomers (the (1R,3R)-stereoisomer exhibits the highest activity). HPA-12 blocks the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus by binding to the START domain of CERT, leading to intracellular ceramide accumulation and inhibition of sphingomyelin (SM) synthesis. HPA-12 induces endoplasmic reticulum stress via the GRP78/ATF6/CHOP axis and activates mitochondrial autophagy, thereby inhibiting cell growth and inducing apoptosis. In in vivo experiments, HPA-12 significantly reduces the leukemia burden and splenomegaly in mouse models of acute myeloid leukemia (AML) and prolongs survival. HPA-12 is applicable for the research of lipid metabolism in acute myeloid leukemia and Alzheimer's disease .
Cat. No.: HY-D1612
CAS No.: 133867-53-5
Cat. No.: HY-D1735
CAS No.: 571186-05-5
Synonyms: Golgi-Red Tracke
Cat. No.: HY-RS02542
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CERT1 Human Pre-designed siRNA Set A contains three designed siRNAs for CERT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20882
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Cert1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cert1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-139404
CAS No.: 1263052-40-9
Synonyms: Anthrylvinyl ceramide; AV Ceramide; AV Ceramide (d18:1/10:0)
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C10 AV Ceramide (d18:1/10:0) is a fluorescent probe. Anthrylvinyl (AV) acts as the fluorescent label positioned on the amide linked acyl chain on the Ceramide molecule to measure the CERT-mediated transfer. The anthrylvinyl moiety of C10 AV Ceramide (d18:1/10:0) localizes to the hydrophobic region of the bilayer .
Cat. No.: HY-RS27399
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Cert1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cert1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P76844
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CERT1; START Domain-Containing Protein 11; Prev. COL4A3BP; Goodpasture Antigen-Binding Protein; STARD11; Lipid-Transfer Protein CERTL; GPBP; Ceramide Transporter; CERT; Sesquipedalian; Ceramide Transfer Protein; StARD11; Collagen, Type IV, Alpha 3 (Goodpa
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
