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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
CFTR trafficking
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "CFTR trafficking" in MCE Product Catalog:
51
51 Publications Verification
Synonyms: VX-445
Research Areas:
Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .
21
21 Cited Publications
Synonyms: VX-809; VRT 826809
Research Areas:
Lumacaftor (VX-809; VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.
5
Target:
Research Areas:
Vanzacaftor (VX-121) is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of CFTR protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and CFTR function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases .
2
2 Cited Publications
Cat. No.: HY-19970
CAS No.: 774549-97-2
Research Areas:
KM11060 is a corrector of the F508 deletion (F508del)-cystic fibrosis transmembrane conductance regulator (CFTR) trafficking defect. KM11060 can be used for the research of F508del-CFTR processing defect and development of cystic fibrosis research .
1
1 Cited Publications
Synonyms: PTI-801 sodium
Target:
Research Areas:
Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF) .
Synonyms: (R)-VX-445
Target:
Research Areas:
(R)-Elexacaftor ((R)-VX-445) is the enantiomer of Elexacaftor (HY-111772). Elexacaftor is an orally active CFTR modulator that targets nucleotide-binding domain 1. Elexacaftor stabilizes misfolded F508del-CFTR protein, enhances its trafficking to the plasma membrane, and significantly improves metabolic stability, thermal stability and ion conductivity. Elexacaftor not only restores chloride transport function in nasal epithelial cells and rescues multiple CFTR mutation subtypes, but also exerts multiplicative synergistic effects with Ivacaftor (HY-13017), and is often used in a triple combination therapy with Tezacaftor (HY-15448). Elexacaftor is widely used in basic and clinical translational research on cystic fibrosis .
Target:
Research Areas:
IDOR-4 is a type IV CFTR corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface .
Cat. No.: HY-145603S
Synonyms: VX-121-d4
Synonyms: (R)-PTI-801 sodium
Target:
Research Areas:
(R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .
Cat. No.: HY-109187
CAS No.: 2095064-05-2
Synonyms: PTI-801
Target:
Research Areas:
Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .
Cat. No.: HY-172555
CAS No.: 2993441-49-7
Target:
Research Areas:
CFTR corrector 18 (Compound I-99) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 18 facilitates the processing and trafficking of CFTR, increasing the number of CFTR on the cell surface. CFTR corrector 18 is promising for research of cystic fibrosis (CF) .
Cat. No.: HY-13262R
CAS No.: 936727-05-8
Synonyms: VX-809 (Standard); VRT 826809 (Standard)
Target:
Research Areas:
Lumacaftor (Standard) is the analytical standard of Lumacaftor. This product is intended for research and analytical applications. Lumacaftor (VX-809; VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.
Cat. No.: HY-111772R
CAS No.: 2216712-66-0
Synonyms: VX-445 (Standard)
Target:
Research Areas:
Elexacaftor (Standard) is the analytical standard of Elexacaftor. This product is intended for research and analytical applications. Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .
Cat. No.: HY-109187AR
CAS No.: 2095064-06-3
Synonyms: PTI-801 sodium (Standard)
Target:
Research Areas:
Posenacaftor sodium (Standard) is the analytical standard of Posenacaftor (sodium) (HY-109187A). This product is intended for research and analytical applications. Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficKing of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF) .
Cat. No.: HY-109187BR
CAS No.: 2095064-09-6
Synonyms: (R)-PTI-801 sodium (Standard)
Target:
Research Areas:
(R)-Posenacaftor sodium (Standard) is the analytical standard of (R)-Posenacaftor (sodium) (HY-109187B). This product is intended for research and analytical applications. (R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficKing of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
