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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
CRL3
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "CRL3" in MCE Product Catalog:
1
1 Cited Publications
Domaines de recherche:
DI-1859 is a DCN1 and cullin 3 inhibitor with a Ki of <1 nM against human DCN1. DI-1859 forms a covalent bond with Cys115 of DCN1, cleaves its dimethylamino group, disrupts the DCN1-UBC12 interaction, and selectively inhibits the neddylation modification of cullin 3 relative to other cullins. DI-1859 inactivates CRL3, promotes the accumulation of NRF2 and SLC7A11, upregulates the expression of HO-1 and NQO1, reduces reactive oxygen species (ROS) levels, enhances insulin signaling, promotes insulin secretion, activates RhoA, regulates the phosphorylation of AKT, without completely blocking the neddylation modification of cullin 3 or restoring the expression of IRS-1. DI-1859 can be used in the research of Acetaminophen (HY-66005)-induced hepatotoxicity, hyperglycemia, metabolic dysfunction-associated steatotic liver disease, insulin resistance, breast cancer and lung cancer [3] .
Cat. No.: HY-156240
CAS No.: 2247060-97-3
Target:
Domaines de recherche:
DI-1548 is a potent, selective, and irreversible covalent inhibitor of DCN1 (IC50 = 4.6 nM). DI-1548 potently and selectively inhibits cullin 3 neddylation at nanomolar concentrations, and exhibits no obvious effect on the neddylation of other cullin members (including cullin 1, 2, 4A, 4B, and 5). DI-1548 exhibits no cytotoxicity. DI-1548 covalently binds to DCN1, disrupting the DCN1-UBC12 interaction, causing the collapse of the neddylation complex, inactivating CRL3, leading to NRF2 accumulation and upregulation of its target genes, and ultimately protecting mice from liver damage. DI-1548 can be used in liver injury research .
Cat. No.: HY-P704146
Pureté: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Interleukin-31 receptor subunit alpha; IL-31R-alpha; IL-31RA; GLM-R; GLM-R; CRL3
Species:
Source:
Cat. No.: HY-P704713
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL-31RA; IL-31R-alpha; Gp130-like receptor; CRL3; GPL; ZcytoR17; GLM-R; CRL3Glmr; GLM-RMGC125346; PRO21384
Cat. No.: HY-P705228
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-31 receptor subunit alpha;
IL-31R-alpha; IL-31RA; GLM-R; GLM-R; CRL3
Cat. No.: HY-RS06755
Target:
Domaines de recherche:
IL31RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL31RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P811003
Synonyms: CRL3, GPL, UNQ6368/PRO21073/PRO21384, IL31RA, Interleukin-31 receptor subunit alpha, IL-31 receptor subunit alpha, IL-31R subunit alpha, IL-31R-alpha, IL-31RA, Cytokine receptor-like 3, GLM-R, Gp130-like monocyte receptor, ZcytoR17, hGLM-R, Gp130-like receptor
Cat. No.: HY-RS20557
Target:
Domaines de recherche:
Il31ra Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il31ra gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
