IL-31R alpha Protein, Cynomolgus (HEK293, His)
Based on 1 Customer Validation
IL-31R alpha Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-31R alpha protein, expressed by HEK293, with C-His tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
IL-31R alpha Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-31R alpha protein, expressed by HEK293, with C-His tag.
Background
The IL-31R alpha protein plays a crucial role in immune response, as it forms the interleukin-31 receptor by associating with OSMR. This receptor activates STAT3, and to a lesser extent, STAT1 and STAT5. It is believed to be involved in skin immunity and mediates IL31-induced itch, potentially relying on cation channels TRPA1 and TRPV1. Additionally, IL-31R alpha positively regulates the numbers and cycling status of immature subsets of myeloid progenitor cells in the bone marrow, both in vivo and in vitro, enhancing myeloid progenitor cell survival. It forms a heterodimer with OSMR and interacts with JAK1 and STAT3.
Verified Bioactivity
Immobilized Cynomolgus IL-31RA, His Tag at 0.5 μg/mL (100 μL/well) on the plate. Dose response curve for Anti-IL-31 RA Antibody, hFc Tag with the EC50 of ≤2.8 ng/mL determined by ELISA.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-8*His
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Accession
XP_045249656.2 (A20-E519)
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Gene ID102117994
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Molecular Construction
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N-term
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IL-31RA (A20-E519)
Accession # XP_045249656.2 -
8*His
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C-term
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Protein Length
Partial
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Synonyms
IL31RA; Cytokine Receptor-Like 3; Interleukin 31 Receptor A; IL-31R Subunit Alpha; GLM-R; HGLM-R; IL-31RA; GPL; CRL3; Soluble Type I Cytokine Receptor CRL3; Interleukin-31 Receptor Subunit Alpha; Class I Cytokine Receptor; Gp130-Like Monocyte Receptor; Gp
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AA Sequence
ALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTAKRTYAFGKKHDNCTTSSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSDMTCWRLEDIAKTEPPEIFSVKPVLGIKRMIQIEWIKPELAPVSSDLKYALRFRTVNSTSWMEVNFAKNRKDTNQTYNLMGLQAFTEYVVALRCAVKESKFWSDWSREKMGMTEEEAPCGLELWRVLKPTEVDGRRPVRLLWKKARGAPVLEKTLGYNIWYFPENNTNLTETVNTTNQQLELHLGGESYWVSMISYNSLGKSPVTTLRIPAIQEKSFRCIEVMQACLAEDQLVVKWQSSALDVNTWMIEWFPDMDSEHPTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGIPSKGPETKVENIGVKTVTITWKDIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYTVRVMASTSAGGINGTSINFKTLSFSVFE
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Predicted Molecular Mass
58.7 kDa
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Molecular Weight
Approximately 90-120 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (238 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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