120 Results for "

D15

" in MedChemExpress (MCE) Product Catalog:
Products (120)

120 Results for "D15" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-132710S
CAS No.: 1447569-77-8
Purity:  99.94%
Tris(1,3-dichloro-2-propyl) Phosphate-d15 is the deuterium labeled Tris(1,3-dichloro-2-propyl) Phosphate .
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Cat. No.: HY-W016414S
CAS No.: 135942-11-9
Triethyl phosphatel-d15 is the deuterium labeled Triethyl phosphate .
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Cat. No.: HY-P1386
CAS No.: 251939-41-0
Synonyms: Dynamin II (828–842)
Target:  

iGluR

Research Areas:  

Neurological Disease

D15, a peptide with 15 aa segment of dynamin, is an AMPAR endocytosis inhibitor. D15 blocks the interaction of dynamin with amphiphysin 1 and 2. D15 significantly increases AMPAR excitatory postsynaptic potential (EPSC) amplitude of medium spiny neurons (MSNs) in Sapap3 KO mice. D15 can be used for neuropsychiatric disorder research .
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Cat. No.: HY-B0402S
CAS No.: 33830-10-3
Synonyms: 1-Adamantanamine-d15; 1-Aminoadamantane-d15
Amantadine-d15 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent .
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Cat. No.: HY-10585S2
CAS No.: 362049-65-8
Purity:  ≥99.0%
Synonyms: VPA-d15; 2-Propylpentanoic acid-d15
Valproic acid-d15 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches .
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Cat. No.: HY-41417S
CAS No.: 69974-55-6
Synonyms: Caprylic acid-d15
Octanoic acid-d15 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
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Cat. No.: HY-169168
CAS No.: 3094190-09-4
Target:  

Transketolase

Research Areas:  

Others

Herbicidal agent 6 (D15) is a Transketolase (TKL) inhibitor with herbicidal activity .
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Cat. No.: HY-W015305S
CAS No.: 1219798-38-5
Ethyl octanoate-d15 is the deuterium labeled Ethyl octanoate.
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Cat. No.: HY-W016473S
CAS No.: 33830-12-5
Adamantane-carboxylic Acid-d15 is the deuterium labeled Adamantane-1-carboxylic acid .
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Cat. No.: HY-W099504S
CAS No.: 194793-95-8
Synonyms: n-Heptyl alcohol-d15
n-Heptyl Alcohol-d15 is the deuterium labeled 1-Heptanol .
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Cat. No.: HY-W776833
CAS No.: 384342-58-9
Synonyms: Otmpmms-15N,d15
MTSSL- 15N,d15-1 (Otmpmms- 15N,d15) is the deuterium and 15N-labeled MTSSL (HY-130509). MTSSL (Otmpmms) is a highly reactive thiol-specific spin label that can be used to label thiol residues in proteins for the determination of protein structure and dynamics, as well as studies on protein-protein interactions. MTSSL serves as a nitroxide labeling reagent for cysteine residues in recombinant mouse prion protein (moPrP C) mutants. MTSSL can be applied in studies of transmissible spongiform encephalopathies (prion diseases) .
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Cat. No.: HY-W011998S
CAS No.: 880462-20-4
Triphenylamine-d15 is the deuterium labeled Triphenylamine .
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Cat. No.: HY-W016577S
CAS No.: 98195-42-7
1-Bromoheptane-d15 is the deuterium labeled 1-Bromoheptane .
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Cat. No.: HY-Y1322S
CAS No.: 1173020-30-8
Synonyms: Celluflex TPP-d15; DHPF 005-d15; Disflamol TP-d15; Disflamoll TP-d15; NSC 57868-d15; Phenyl phosphate ((PhO)3PO)-d15; Phoscon FR 903N-d15
Triphenyl phosphate-d15 is the deuterium labeled Triphenyl phosphate. Triphenyl phosphate is an orally active, blood-brain barrier-permeable aryl organophosphate flame retardant and endocrine disruptor. Triphenyl phosphate disrupts mitochondrial dynamic balance through oxidative stress, induces excessive mitophagy and apoptosis, and ultimately leads to myocardial fibrosis. In the brain, Triphenyl phosphate activates the NF-κB inflammatory pathway by disrupting the gut microbiota, alters tryptophan metabolism and elevates neurotoxins, thereby inducing anxiety- and depression-like behaviors. In the skeletal and reproductive systems, Triphenyl phosphate inhibits osteoblast differentiation and induces germ cell apoptosis by suppressing the MAPK/ERK pathway and activating the JNK signal, respectively. In adipose and placental tissues, Triphenyl phosphate promotes lipid accumulation by activating the PI3K/AKT-PPARγ axis, and disrupts placental metabolism via the MAOA/ROS/NF-κB cascade, impairing neurodevelopment of offspring.
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Cat. No.: HY-131134S
Synonyms: Fosetyl-Al-d15
Fosetyl-aluminum-d15 (Fosetyl-Al-d15) is the deuterium labeled Fosetyl-aluminum. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops .
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Cat. No.: HY-17367S
CAS No.: 1092540-56-1
Synonyms: BMS-232632-d15
Atazanavir-d15 is the d15 labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .
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Cat. No.: HY-100516
CAS No.: 265114-23-6
Purity:  98.02%
Synonyms: UR-8880
Target:  

COX Cytochrome P450

Research Areas:  

Inflammation/Immunology

Cimicoxib (UR-8880) is an orally active, blood-brain barrier-permeable COX-2 inhibitor that also exerts targeted inhibition on CYP2D15. It has an IC50 of 66 nM against hCOX-2, an IC50 of 1.6 μM against canine CYP2D15, and an IC50 of 0.056 μM against feline CYP2D15. By inhibiting the COX-2 pathway to reduce the production of thromboxane B2 and prostaglandin E2, Cimicoxib exerts antipyretic, anti-inflammatory and analgesic effects. Cimicoxib is metabolized by CYP2D15 to form demethyl-cimicoxib, undergoes glucuronidation via UDP-glucuronosyltransferases, and exhibits biphasic elimination kinetics in beagle dogs. Cimicoxib is widely used in studies of inflammatory diseases, osteoarthritis, and perioperative pain associated with orthopedic or soft tissue surgeries .
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Cat. No.: HY-A0181S4
Synonyms: AMP-13C10,15N5,d12 dilithium
Adenosine monophosphate- 13C10, 15N5,d12 (AMP- 13C10, 15N5,d12) dilithium is 13C and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction .
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Cat. No.: HY-N0455AS4
CAS No.: 2483829-29-2
Synonyms: (S)-(+)-Arginine-13C6,15N4,d7 hydrochloride
L-Arginine- 13C6, 15N4,d7 (hydrochloride) is the deuterium, 13C-, and 15-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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Cat. No.: HY-126573S
CAS No.: 1219805-25-0
Trilaurin-d15 is the deuterium labeled Trilaurin.
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