Amantadine-d15
Based on 1 Customer Validation
Amantadine-d15 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 33830-10-3
- Formula: C10H2D15N
- Molecular Weight:166.34
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 33830-10-3
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Unlabeled Cas 768-94-5
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Appearance Solid
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Molecular Weight 166.34
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Formula C10H2D15N
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Color White to off-white
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SMILES
[2H]C1([2H])C2(C([2H])([2H])[C@@](C3([2H])[2H])([2H])C([2H])([2H])[C@]1([2H])C([2H])([2H])[C@@]3([2H])C2([2H])[2H])N
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Synonyms
1-Adamantanamine-d15; 1-Aminoadamantane-d15
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 10 mg/mL (60.12 mM; ultrasonic and adjust pH to 2 with 1M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (778 KB)
- English - EN (778 KB)
- Français - FR (778 KB)
- Deutsch - DE (778 KB)
- Norwegian - NO (778 KB)
- Español - ES (778 KB)
- Swedish - SV (778 KB)
- Italian - IT (778 KB)
- Korean - KR (778 KB)
- Portuguese - PT (778 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. [Content Brief]
[3]. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.0118 mL | 30.0589 mL | 60.1178 mL | 150.2946 mL |
| 5 mM | 1.2024 mL | 6.0118 mL | 12.0236 mL | 30.0589 mL | |
| 10 mM | 0.6012 mL | 3.0059 mL | 6.0118 mL | 15.0295 mL | |
| 15 mM | 0.4008 mL | 2.0039 mL | 4.0079 mL | 10.0196 mL | |
| 20 mM | 0.3006 mL | 1.5029 mL | 3.0059 mL | 7.5147 mL | |
| 25 mM | 0.2405 mL | 1.2024 mL | 2.4047 mL | 6.0118 mL | |
| 30 mM | 0.2004 mL | 1.0020 mL | 2.0039 mL | 5.0098 mL | |
| 40 mM | 0.1503 mL | 0.7515 mL | 1.5029 mL | 3.7574 mL | |
| 50 mM | 0.1202 mL | 0.6012 mL | 1.2024 mL | 3.0059 mL | |
| 60 mM | 0.1002 mL | 0.5010 mL | 1.0020 mL | 2.5049 mL |
Amantadine-d15 Related Classifications
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