2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. D15

D15  (Synonyms: Dynamin II (828–842))

Cat. No.: HY-P1386 Purity: 99.02%
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D15, a peptide with 15 aa segment of dynamin, is an AMPAR endocytosis inhibitor. D15 blocks the interaction of dynamin with amphiphysin 1 and 2. D15 significantly increases AMPAR excitatory postsynaptic potential (EPSC) amplitude of medium spiny neurons (MSNs) in Sapap3 KO mice. D15 can be used for neuropsychiatric disorder research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

D15

D15 Chemical Structure

CAS No. : 251939-41-0

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Based on 1 publication(s) in Google Scholar

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Description

D15, a peptide with 15 aa segment of dynamin, is an AMPAR endocytosis inhibitor. D15 blocks the interaction of dynamin with amphiphysin 1 and 2. D15 significantly increases AMPAR excitatory postsynaptic potential (EPSC) amplitude of medium spiny neurons (MSNs) in Sapap3 KO mice. D15 can be used for neuropsychiatric disorder research[1].

IC50 & Target[1]

AMPA Receptor

 

Clinical Trial
Molecular Weight

1566.76

Formula

C69H111N23O19
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Pro-Pro-Pro-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-Pro-Gly
Sequence Shortening

PPPQVPSRPNRAPPG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (63.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6383 mL 3.1913 mL 6.3826 mL
5 mM 0.1277 mL 0.6383 mL 1.2765 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6383 mL 3.1913 mL 6.3826 mL 15.9565 mL
5 mM 0.1277 mL 0.6383 mL 1.2765 mL 3.1913 mL
10 mM 0.0638 mL 0.3191 mL 0.6383 mL 1.5956 mL
15 mM 0.0426 mL 0.2128 mL 0.4255 mL 1.0638 mL
20 mM 0.0319 mL 0.1596 mL 0.3191 mL 0.7978 mL
25 mM 0.0255 mL 0.1277 mL 0.2553 mL 0.6383 mL
30 mM 0.0213 mL 0.1064 mL 0.2128 mL 0.5319 mL
40 mM 0.0160 mL 0.0798 mL 0.1596 mL 0.3989 mL
50 mM 0.0128 mL 0.0638 mL 0.1277 mL 0.3191 mL
60 mM 0.0106 mL 0.0532 mL 0.1064 mL 0.2659 mL
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D15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D15251939-41-0Dynamin II (828–842)D 15D-15iGluRIonotropic glutamate receptorsPeptideAMPAREndocytosisInhibitorMedium spiny neuronsMSNEPSCNeuropsychiatric disorderinhibitorinhibit

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