1. Cell Cycle/DNA Damage Epigenetics Autophagy Anti-infection Neuronal Signaling Stem Cell/Wnt Metabolic Enzyme/Protease
  2. HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite
  3. Valproic acid-d15

Valproic acid-d15  (Synonyms: VPA-d15; 2-Propylpentanoic Acid-d15)

Cat. No.: HY-10585S2 Purity: ≥99.0%
COA Handling Instructions

Valproic acid-d15 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

For research use only. We do not sell to patients.

Valproic acid-d<sub>15</sub> Chemical Structure

Valproic acid-d15 Chemical Structure

CAS No. : 362049-65-8

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Based on 1 publication(s) in Google Scholar

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Description

Valproic acid-d15 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

159.30

Formula

C8HD15O2

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C(C(O)=O)([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

References
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