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DENV-1

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By Targets:	Dengue Virus (9) Antibiotic (1) DNA/RNA Synthesis (1) Flavivirus (5) Virus Protease (5)
By Research Areas:	Infection (9)

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Targets Recommended: Dengue Virus

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138543

NITD-688 EYU-688	Flavivirus Dengue Virus Virus Protease	Infection
NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV) .

HY-144645

SP-471P	Flavivirus Dengue Virus Virus Protease DNA/RNA Synthesis	Infection
SP-471P is a potent *dengue virus (DENV) protease* inhibitor with EC₅₀s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC₅₀ value over 100 μM. SP-471P can reduce DENV viral RNA synthesis ^[1].

HY-162485

DV-B-120	Dengue Virus Virus Protease	Infection
DV-B-120 is a competitive inhibitor for dengue virus (DENV) with IC₅₀s of 5.35, 7.39, 10.49 and 8.58 μM, for DENV-1, DENV-2, DENV-3 and DENV-4, respectively, by inhibiting NS2B-NS3 protease. DV-B-120 exhibits antiviral activity through inhibition of DENV replication ^[1].

HY-149467

JMX0254	Dengue Virus Virus Protease	Infection
JMX0254 is an orally active and potent inhibitor of the dengue virus NS4B protein. JMX0254’s EC₅₀ for DENV-1, DENV-2, and DENV-3 are 0.78 µM, 0.16 µM, and 0.035 µM, respectively. JMX0254 can be used for research on viral infections ^[1].

HY-144646

SP-471	Flavivirus Dengue Virus Virus Protease	Infection
SP-471 is a potent *dengue virus (DENV) protease* inhibitor with IC₅₀ value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV .

HY-147761

GAK inhibitor 2	Antibiotic Flavivirus Dengue Virus	Infection
GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC₅₀ of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC₅₀ of 1.049 μM against dengue virus (DENV) .

HY-149251

DENV-IN-10	Flavivirus Dengue Virus	Infection
DENV-IN-10 is a potent tetravalent dengue inhibitor, with EC₅₀s of 1.36, 0.87, 0.94, and 0.95 μM against *DENV-1-4* serotypes, respectively. DENV-IN-10 is a post-entry replication inhibitor that appears to be specific for cells of primate origin ^[1].

HY-157550

DENV-IN-12	Dengue Virus	Infection
DENV-IN-12 (Compound 6) is a derivative of N-methylcytisine thio, which inhibits *DENV-1* and *DENV-2. DENV-IN-12 displays robust antiviral activity against DENV-2, with EC₅₀* values ranging from 0.002 to 0.005 μM in different cell lines ^[1].

HY-N12407

Peridinin	Dengue Virus	Infection
Peridinin is a hydroxylated carotenoid ketone that exhibits inhibitory activity against DENV NS2B/NS3 protease and all dengue virus serotypes (DENV-1, *DENV-2, DENV-3, DENV-4*). Peridinin inhibits dengue virus production and reduces viral titers. Peridinin is applicable to research related to dengue virus infection ^[1].

Peridinin	Structural Classification Natural Products Classification of Application Fields Ketones, Aldehydes, Acids Marine natural products Other marine organisms Pigments Source Classification Food Research	Dengue Virus
Peridinin is a hydroxylated carotenoid ketone that exhibits inhibitory activity against DENV NS2B/NS3 protease and all dengue virus serotypes (DENV-1, *DENV-2, DENV-3, DENV-4*). Peridinin inhibits dengue virus production and reduces viral titers. Peridinin is applicable to research related to dengue virus infection ^[1].

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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DENV-1

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