DENV-IN-10
DENV-IN-10 is a potent tetravalent dengue inhibitor, with EC50s of 1.36, 0.87, 0.94, and 0.95 μM against DENV-1-4 serotypes, respectively. DENV-IN-10 is a post-entry replication inhibitor that appears to be specific for cells of primate origin.
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- No. CAS: 3043724-36-0
- Fòrmula: C26H25N3O4S
- Peso molecular:475.56
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>100 μM
Compound: 26
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 36965228] |
| BHK-21 | CC50 |
>25 μM
Compound: 26
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Cytotoxicity against hamster BHK-21 cells
Cytotoxicity against hamster BHK-21 cells
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[PMID: 36965228] |
| Calu-1 | CC50 |
>100 μM
Compound: 26
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Cytotoxicity against human Calu-1 cells
Cytotoxicity against human Calu-1 cells
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[PMID: 36965228] |
| Huh-7 | CC50 |
>100 μM
Compound: 26
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Cytotoxicity against human Huh-7 cells
Cytotoxicity against human Huh-7 cells
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[PMID: 36965228] |
| Huh-7 | CC50 |
>100 μM
Compound: 26
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Cytotoxicity against human Huh-7 cells treated for 48 hrs measured by celltitre-glo luminescent assay
Cytotoxicity against human Huh-7 cells treated for 48 hrs measured by celltitre-glo luminescent assay
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[PMID: 36965228] |
| Vero | CC50 |
>25 μM
Compound: 26
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Cytotoxicity against green monkey Vero cells
Cytotoxicity against green monkey Vero cells
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[PMID: 36965228] |
In Vitro
DENV-IN-10 (compound 26) (10 μM; added either prior to DENV infection, during infection (0 h) or at different time points post-infection (2, 6, 12, 24 hpi)) exhibits no significant antiviral activity after pre- and co-treatment and reduces the level of infectious viral particles at 2 h post-infection and remained effective even when added at 24 h post-infection[1].
DENV-IN-10 (10 μM; 24-60 h) reduces the viral RNA copy numbers and the expression of viral proteins NS3 and NS5 in Huh-7 cells infected with DENV-2[1].
DENV-IN-10 (0.1-20 μM) significantly inhibits DENV-2 replication in primate cell lines but EC50s are higher in mosquito cells and baby hamster kidney cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3043724-36-0
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Peso molecular 475.56
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Fòrmula C26H25N3O4S
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SMILES
CCCOC1=CC=C(C(C(NCC2=CC=CC=C2)=O)=C1)NS(=O)(C3=CC=CC4=C3N=CC=C4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DENV-IN-10 Related Classifications
HY-149251 Related Classifications
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