DENV-IN-10 

DENV-IN-10 is a potent tetravalent dengue inhibitor, with EC₅₀s of 1.36, 0.87, 0.94, and 0.95 μM against DENV-1-4 serotypes, respectively. DENV-IN-10 is a post-entry replication inhibitor that appears to be specific for cells of primate origin^[1].

DENV-IN-10 (compound 26) (10 μM; added either prior to DENV infection, during infection (0 h) or at different time points post-infection (2, 6, 12, 24 hpi)) exhibits no significant antiviral activity after pre- and co-treatment and reduces the level of infectious viral particles at 2 h post-infection and remained effective even when added at 24 h post-infection^[1].
DENV-IN-10 (10 μM; 24-60 h) reduces the viral RNA copy numbers and the expression of viral proteins NS3 and NS5 in Huh-7 cells infected with DENV-2^[1].
DENV-IN-10 (0.1-20 μM) significantly inhibits DENV-2 replication in primate cell lines but EC₅₀s are higher in mosquito cells and baby hamster kidney cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

475.56

C₂₆H₂₅N₃O₄S

CCCOC1=CC=C(C(C(NCC2=CC=CC=C2)=O)=C1)NS(=O)(C3=CC=CC4=C3N=CC=C4)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Felicetti T, et, al. Functionalized sulfonyl anthranilic acid derivatives inhibit replication of all the four dengue serotypes. Eur J Med Chem. 2023 Apr 5;252:115283.  [Content Brief]