GAK inhibitor 2
Based on 1 Customer Validation
GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC50 of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC50 of 1.049 μM against dengue virus (DENV).
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- Pureté: 98.58%
- CAS No.: 2396706-31-1
- Formule: C20H23N3O3S
- Masse moléculaire:385.48
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
IC50: 0.024 μM (GAK)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>10 μM
Compound: 14g
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Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue reagent based cell viability assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue reagent based cell viability assay
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[PMID: 31757682] |
| Huh-7 | EC50 |
1.049 μM
Compound: 14g
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Antiviral activity against Dengue virus 2 infected in human HuH7 cells incubated for 48 hrs by luciferase reporter gene assay
Antiviral activity against Dengue virus 2 infected in human HuH7 cells incubated for 48 hrs by luciferase reporter gene assay
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[PMID: 31757682] |
| Huh7.5.1 | CC50 |
>10 μM
Compound: 86
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Cytotoxicity against human Huh-7.5.1 cells
Cytotoxicity against human Huh-7.5.1 cells
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[PMID: 33539089] |
Chemical Information
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CAS No. 2396706-31-1
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Appearance Solid
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Masse moléculaire 385.48
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Formule C20H23N3O3S
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Color Light yellow to yellow
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SMILES
COC1=CC=C(C2=NC3=C(N4C[C@@H](C)O[C@@H](C)C4)SN=C3C=C2)C=C1OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 33.33 mg/mL (86.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5942 mL | 12.9708 mL | 25.9417 mL | 64.8542 mL |
| 5 mM | 0.5188 mL | 2.5942 mL | 5.1883 mL | 12.9708 mL | |
| 10 mM | 0.2594 mL | 1.2971 mL | 2.5942 mL | 6.4854 mL | |
| 15 mM | 0.1729 mL | 0.8647 mL | 1.7294 mL | 4.3236 mL | |
| 20 mM | 0.1297 mL | 0.6485 mL | 1.2971 mL | 3.2427 mL | |
| 25 mM | 0.1038 mL | 0.5188 mL | 1.0377 mL | 2.5942 mL | |
| 30 mM | 0.0865 mL | 0.4324 mL | 0.8647 mL | 2.1618 mL | |
| 40 mM | 0.0649 mL | 0.3243 mL | 0.6485 mL | 1.6214 mL | |
| 50 mM | 0.0519 mL | 0.2594 mL | 0.5188 mL | 1.2971 mL | |
| 60 mM | 0.0432 mL | 0.2162 mL | 0.4324 mL | 1.0809 mL | |
| 80 mM | 0.0324 mL | 0.1621 mL | 0.3243 mL | 0.8107 mL |
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