2. Anti-infection
  3. Dengue virus Flavivirus Virus Protease
  4. NITD-688

NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV).

For research use only. We do not sell to patients.

NITD-688 Chemical Structure

NITD-688 Chemical Structure

CAS No. : 2407227-31-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1983 In-stock
Solution
10 mM * 1 mL in DMSO USD 1983 In-stock
Solid
1 mg USD 450 In-stock
5 mg USD 1800 In-stock
10 mg USD 2850 In-stock
25 mg USD 5800 In-stock
50 mg USD 9250 In-stock
100 mg USD 14800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

NITD-688 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV)[1].

IC50 & Target

NS4B[1]
In Vitro

NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC50 values of 8 to 38 nM[1].
NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC50 value of 0.94 nM[1].
NITD-688 directly binds to wild-type but not mutant NS4B protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NITD-688 Related Antibodies
In Vivo

NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice[1].
NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Infected AG129 mice[1]
Dosage: 30 mg/kg
Administration: Oral gavage, twice daily for 3 days
Result: Resulted in a 1.16-log reduction in viremia.
Molecular Weight

500.68

Formula

C25H32N4O3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC(C(CN1CC2CCCCC2)=C(CC(C)1C)S3)=C3NC(CC(C=C4)=CC=C4[S](N)(=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (199.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9973 mL 9.9864 mL 19.9728 mL
5 mM 0.3995 mL 1.9973 mL 3.9946 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9973 mL 9.9864 mL 19.9728 mL 49.9321 mL
5 mM 0.3995 mL 1.9973 mL 3.9946 mL 9.9864 mL
10 mM 0.1997 mL 0.9986 mL 1.9973 mL 4.9932 mL
15 mM 0.1332 mL 0.6658 mL 1.3315 mL 3.3288 mL
20 mM 0.0999 mL 0.4993 mL 0.9986 mL 2.4966 mL
25 mM 0.0799 mL 0.3995 mL 0.7989 mL 1.9973 mL
30 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.6644 mL
40 mM 0.0499 mL 0.2497 mL 0.4993 mL 1.2483 mL
50 mM 0.0399 mL 0.1997 mL 0.3995 mL 0.9986 mL
60 mM 0.0333 mL 0.1664 mL 0.3329 mL 0.8322 mL
80 mM 0.0250 mL 0.1248 mL 0.2497 mL 0.6242 mL
100 mM 0.0200 mL 0.0999 mL 0.1997 mL 0.4993 mL
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NITD-688 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NITD-6882407227-31-8NITD688NITD 688Dengue virusFlavivirusVirus ProteaseDENVAG129PBMCInhibitorinhibitorinhibit

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