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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
273 Results for "
Drug development
" in MedChemExpress (MCE) Product Catalog:
Products (273)
273 Results for "Drug development" in MCE Product Catalog:
3
3 Cited Publications
Art. -Nr.: HY-K1099
MCE Endotoxin Detection Kit (Recombinant Factor C) is suitable for the detection of endotoxins in therapeutic injectable drugs for human use (such as chemical drugs, antibiotics, and biologics), as well as in medical devices including dialysis fluids and implantable devices. It can be applied throughout raw material screening, process development, manufacturing, and commercialization stages.
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3 Cited Publications
Art. -Nr.: HY-P1291
CAS. Nr.: 201422-03-9
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3
3 Cited Publications
Art. -Nr.: HY-P1291A
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3
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1
1 Cited Publications
Art. -Nr.: HY-W127512
CAS. Nr.: 546-18-9
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5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems .
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1 Cited Publications
Synonyms: PBI-0451
Pomotrelvir is a selective, competitive, orally active covalent inhibitor of the SARS-CoV-2 main protease (M pro), with an IC50 of 24 nM for wild-type SARS-CoV-2 M pro. Pomotrelvir inhibits viral polyprotein processing, thereby preventing viral replication. Pomotrelvir has shown broad antiviral activity against multiple SARS-CoV-2 variants (including Omicron) in cell-based experiments, and has an additive effect when combined with nucleoside analogs that target viral RNA synthesis. Pomotrelvir is primarily used for the research and development of COVID-19 antiviral drugs, especially for infections caused by SARS-CoV-2 and its variants .
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Tropinone is an organic synthesis intermediate and a skeleton for constructing derivatives containing thiazole rings and other structures. Tropinone derivatives have anticancer activities such as inducing tumor cell apoptosis and inhibiting tyrosinase activity, and can be used in research such as anticancer drug development and tyrosinase inhibitor design .
Art. -Nr.: HY-W048488
CAS. Nr.: 163759-49-7
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2'-O-MOE-5-Me-rU is a dual chemically modified ribonucleoside, which is a key modifying unit in the development of RNA drug preparations (such as antisense oligonucleotides ASO, siRNA). Its core function is to significantly enhance the stability, target affinity and drugability of nucleic acid drugs.
Art. -Nr.: HY-170528
CAS. Nr.: 2249926-63-2
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DBCO-PEG3-NHS is a biochemical assay reagent, that can be used to chemically modify proteins and antibodies with an alkynyl (DBCO) or N-hydroxysuccinimide (NHS) ester group. DBCO-PEG3-NHS can be used as a linker in PROTAC synthesis or for drug delivery and the development of biosensors and diagnostic reagents .
Art. -Nr.: HY-P2112
CAS. Nr.: 619300-53-7
Synonyms: DOTA-Nal3-octreotide
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Art. -Nr.: HY-42709
CAS. Nr.: 24787-89-1
Synonyms: Carbobenzoxy-L-valyl-L-alanine
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Art. -Nr.: HY-W127702
CAS. Nr.: 6106-46-3
Synonyms: Methscopolamine nitrate
Art. -Nr.: HY-P5313A
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Art. -Nr.: HY-151748
CAS. Nr.: 1994267-98-9
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N3-L-Orn(Fmoc)-OH is a non-natural amino acid building block specially designed for solid-phase peptide synthesis and click chemistry. N3-L-Orn(Fmoc)-OH can be used as a linker for ADC (antibody-drug conjugate) or for the development of targeting peptides.
Art. -Nr.: HY-148316
CAS. Nr.: 186610-88-8
hVEGF-IN-2 (compound 19) is a selective VEGF (Flk-1) receptor tyrosine kinases (RTK) inhibitor with an IC50 value of 2.5 μM. hVEGF-IN-2 inhibits PDGF RTK activity with an IC50 value of 33.1 μM. hVEGF-IN-2 can be used for the development of RTK-specific agents .
Art. -Nr.: HY-W190923
CAS. Nr.: 2353409-70-6
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MMAF-methyl ester is a methylated derivative of the tubulin inhibitor MMAF (HY-15579), and serves as a pharmaceutical intermediate for the development of antibody-drug conjugates (ADCs) and small-molecule drug conjugates (SMDCs) .
Art. -Nr.: HY-44370
CAS. Nr.: 330807-97-1
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(tert-Butoxycarbonyl)glycyl-glycyl-glycyl-glycyl-glycine is an ADC linker with a Boc group on the N terminus, and it is used for the development of antibody-drug conjugates (ADCs). The Boc group can be deprotected under mild acidic conditions to form the free amine.
Art. -Nr.: HY-128753S6
CAS. Nr.: 288846-88-8
Art. -Nr.: HY-151736
CAS. Nr.: 1932432-15-9
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N3-L-Dap(Boc)-OH is a non-natural amino acid building block specially designed for solid-phase peptide synthesis and click chemistry. N3-L-Dap(Boc)-OH can be used as a linker for ADC (antibody-drug conjugate) or for the development of targeting peptides.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
