2. Anti-infection
  3. SARS-CoV
  4. Pomotrelvir

Pomotrelvir  (Synonyms: PBI-0451)

Cat. No.: HY-153228 Purity: ≥95.0%
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Pomotrelvir (PBI-0451) is a selective, orally active SARS-CoV-2 3CL protease inhibitor. Pomotrelvir has antiviral activity and can be used in the research of novel coronavirus (COVID-19).

For research use only. We do not sell to patients.

Pomotrelvir Chemical Structure

Pomotrelvir Chemical Structure

CAS No. : 2713437-86-4

Size Price Stock Quantity
1 mg USD 413 In-stock
5 mg USD 950 In-stock
10 mg USD 1510 In-stock
25 mg USD 3180 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Pomotrelvir Related Antibodies

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Description

Pomotrelvir (PBI-0451) is a selective, orally active SARS-CoV-2 3CL protease inhibitor. Pomotrelvir has antiviral activity and can be used in the research of novel coronavirus (COVID-19)[1].

Clinical Trial
Molecular Weight

455.94

Formula

C23H26ClN5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=C2C(C=C(N2)C(N[C@H](C(N[C@H](C#N)C[C@H]3C(NCCC3)=O)=O)CC4CC4)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1933 mL 10.9664 mL 21.9327 mL
5 mM 0.4387 mL 2.1933 mL 4.3865 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1933 mL 10.9664 mL 21.9327 mL 54.8318 mL
5 mM 0.4387 mL 2.1933 mL 4.3865 mL 10.9664 mL
10 mM 0.2193 mL 1.0966 mL 2.1933 mL 5.4832 mL
15 mM 0.1462 mL 0.7311 mL 1.4622 mL 3.6555 mL
20 mM 0.1097 mL 0.5483 mL 1.0966 mL 2.7416 mL
25 mM 0.0877 mL 0.4387 mL 0.8773 mL 2.1933 mL
30 mM 0.0731 mL 0.3655 mL 0.7311 mL 1.8277 mL
40 mM 0.0548 mL 0.2742 mL 0.5483 mL 1.3708 mL
50 mM 0.0439 mL 0.2193 mL 0.4387 mL 1.0966 mL
60 mM 0.0366 mL 0.1828 mL 0.3655 mL 0.9139 mL
80 mM 0.0274 mL 0.1371 mL 0.2742 mL 0.6854 mL
100 mM 0.0219 mL 0.1097 mL 0.2193 mL 0.5483 mL
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Pomotrelvir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomotrelvir2713437-86-4PBI-0451PBI0451PBI 0451SARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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