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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
EBI2
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "EBI2" in MCE Product Catalog:
4
Target:
3
3 Cited Publications
Target:
Research Areas:
NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases .
3
3 Cited Publications
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Research Areas:
GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.
1
1 Cited Publications
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ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity .
Cat. No.: HY-W414548
CAS No.: 4725-24-0
Research Areas:
7α,27-Dihydroxycholesterol is an oxysterol, a human metabolite, and a ligand for EBI2 (GPR183), which is involved in lipid synthesis. 7α,27-Dihydroxycholesterol mediates the chemotaxis of cells expressing EBI2. 7α,27-Dihydroxycholesterol can be converted into 7α,27-dihydroxy-4-cholesten-3-one (HY-W414457), thereby inhibiting HMG-CoA reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis [2] .
Cat. No.: HY-N10493
CAS No.: 64907-21-7
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Cat. No.: HY-113962S
CAS No.: 2260669-11-0
Synonyms: 7α,25-OHC-d6
Cat. No.: HY-400897
CAS No.: 1326612-12-7
Research Areas:
7α,25-Dihydroxycholesterol intermediate-1 is an intermediate in the synthesis of 7α,25-Dihydroxycholesterol (HY-113962). 7α,25-Dihydroxycholesterol (7α,25-OHC) can be used as a ligand to target the orphan GPCR receptor EBI2 (GPR183). body, used to synthesize the corresponding PROTEACs .
Cat. No.: HY-101192R
CAS No.: 1334294-76-6
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GSK682753A (Standard) is the analytical standard of GSK682753A (HY-101192). This product is intended for research and analytical applications. GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.
Cat. No.: HY-RS05691
Research Areas:
Gpr183 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr183 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS05692
Research Areas:
Gpr183 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gpr183 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS05690
Research Areas:
GPR183 Human Pre-designed siRNA Set A contains three designed siRNAs for GPR183 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
