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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
Fli-1
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "Fli-1" in MCE Product Catalog:
9
9 Cited Publications
Target:
Research Areas:
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor [1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .
7
7 Cited Publications
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YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer [1] .
Cat. No.: HY-RS04977
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FLI1 Human Pre-designed siRNA Set A contains three designed siRNAs for FLI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-173364
CAS No.: 3114073-95-6
Synonyms: BAK-04-212
EB-TCIP (BAK-04-212) is a proof-of-concept tool specifically designed for Ewing sarcoma research, serving as an EWSR1::FLI1 binder tagged with BCL6 and FKBP12 F36V. EB-TCIP forms a ternary complex with the tagged fusion protein, specifically recruits EWSR1::FLI1 to BCL6-bound DNA loci, and induces rapid chromatin remodeling and relocalization. By mediating relocalization, EB-TCIP remodels the transcriptional machinery and activates the expression of BCL6 target genes that are originally repressed. EB-TCIP is used in studies related to novel epigenetic therapies for Ewing sarcoma [1].
Cat. No.: HY-122903S
CAS No.: 3034816-36-6
Cat. No.: HY-RS18357
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Fli1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fli1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-163325
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Fli-1-IN-1 (compound 21) fumarate is a FLI1 targeting agent that directly binds to and inhibits the EWS-FLI1 protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 fumarate inhibits EWS-FLI1 and has potential anticancer activity [1].
Cat. No.: HY-163325A
CAS No.: 3027140-81-1
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Fli-1-IN-1 (compound 21) is a FLI1 targeting agent that directly binds to and inhibits the EWS-FLI1 protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 inhibits EWS-FLI1 and has potential anticancer activity [1].
Cat. No.: HY-RS24836
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Fli1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fli1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P703126
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB; Fli1; Homo sapiens; Human; Activator; DNA-binding
Cat. No.: HY-P703127
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB; Fli1; Homo sapiens; Human; Activator; DNA-binding
Cat. No.: HY-RS04978
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FLII Human Pre-designed siRNA Set A contains three designed siRNAs for FLII gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
